Impact of uncertain head tissue conductivity in the optimization of transcranial direct current stimulation for an auditory target

Beitrag in einer Fachzeitschrift


Details zur Publikation

Autorinnen und Autoren: Schmidt C, Wagner S, Burger M, Van Rienen U, Wolters CH
Zeitschrift: Journal of Neural Engineering
Verlag: Institute of Physics Publishing
Jahr der Veröffentlichung: 2015
Band: 12
ISSN: 1741-2560
Sprache: Englisch


Abstract

Objective. Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique to modify neural excitability. Using multi-array tDCS, we investigate the influence of inter-individually varying head tissue conductivity profiles on optimal electrode configurations for an auditory cortex stimulation. Approach. In order to quantify the uncertainty of the optimal electrode configurations, multi-variate generalized polynomial chaos expansions of the model solutions are used based on uncertain conductivity profiles of the compartments skin, skull, gray matter, and white matter. Stochastic measures, probability density functions, and sensitivity of the quantities of interest are investigated for each electrode and the current density at the target with the resulting stimulation protocols visualized on the head surface. Main results. We demonstrate that the optimized stimulation protocols are only comprised of a few active electrodes, with tolerable deviations in the stimulation amplitude of the anode. However, large deviations in the order of the uncertainty in the conductivity profiles could be noted in the stimulation protocol of the compensating cathodes. Regarding these main stimulation electrodes, the stimulation protocol was most sensitive to uncertainty in skull conductivity. Finally, the probability that the current density amplitude in the auditory cortex target region is supra-threshold was below 50%. Significance. The results suggest that an uncertain conductivity profile in computational models of tDCS can have a substantial influence on the prediction of optimal stimulation protocols for stimulation of the auditory cortex. The investigations carried out in this study present a possibility to predict the probability of providing a therapeutic effect with an optimized electrode system for future auditory clinical and experimental procedures of tDCS applications.


Einrichtungen weiterer Autorinnen und Autoren

Universität Rostock
Westfälische Wilhelms-Universität (WWU) Münster


Zitierweisen

APA:
Schmidt, C., Wagner, S., Burger, M., Van Rienen, U., & Wolters, C.H. (2015). Impact of uncertain head tissue conductivity in the optimization of transcranial direct current stimulation for an auditory target. Journal of Neural Engineering, 12. https://dx.doi.org/10.1088/1741-2560/12/4/046028

MLA:
Schmidt, Christian, et al. "Impact of uncertain head tissue conductivity in the optimization of transcranial direct current stimulation for an auditory target." Journal of Neural Engineering 12 (2015).

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Zuletzt aktualisiert 2018-04-12 um 09:23