Influences of skull segmentation inaccuracies on EEG source analysis.
Lanfer B, Scherg M, Dannhauer M, Knoesche TR, Burger M, Wolters CH (2012)
Publication Language: English
Publication Type: Journal article
Publication year: 2012
Journal
Book Volume: 62
Pages Range: 418-31
Issue: 1
DOI: 10.1016/j.neuroimage.2012.05.006
Abstract
The low-conducting human skull is known to have an especially large influence on electroencephalography (EEG) source analysis. Because of difficulties segmenting the complex skull geometry out of magnetic resonance images, volume conductor models for EEG source analysis might contain inaccuracies and simplifications regarding the geometry of the skull. The computer simulation study presented here investigated the influences of a variety of skull geometry deficiencies on EEG forward simulations and source reconstruction from EEG data. Reference EEG data was simulated in a detailed and anatomically plausible reference model. Test models were derived from the reference model representing a variety of skull geometry inaccuracies and simplifications. These included erroneous skull holes, local errors in skull thickness, modeling cavities as bone, downward extension of the model and simplifying the inferior skull or the inferior skull and scalp as layers of constant thickness. The reference EEG data was compared to forward simulations in the test models, and source reconstruction in the test models was performed on the simulated reference data. The finite element method with high-resolution meshes was employed for all forward simulations. It was found that large skull geometry inaccuracies close to the source space, for example, when cutting the model directly below the skull, led to errors of 20mm and more for extended source space regions. Local defects, for example, erroneous skull holes, caused non-negligible errors only in the vicinity of the defect. The study design allowed a comparison of influence size, and guidelines for modeling the skull geometry were concluded.
Authors with CRIS profile
Involved external institutions
Westfälische Wilhelms-Universität (WWU) Münster
Germany (DE)
BESA GmbH
Germany (DE)
Max-Planck-Institut für Kognitions- und Neurowissenschaften / Max Planck Institute for Human Cognitive and Brain Sciences
Germany (DE)
Germany (DE)
BESA GmbH
Germany (DE)
Max-Planck-Institut für Kognitions- und Neurowissenschaften / Max Planck Institute for Human Cognitive and Brain Sciences
Germany (DE)
How to cite
APA:
Lanfer, B., Scherg, M., Dannhauer, M., Knoesche, T.R., Burger, M., & Wolters, C.H. (2012). Influences of skull segmentation inaccuracies on EEG source analysis. NeuroImage, 62, 418-31. https://dx.doi.org/10.1016/j.neuroimage.2012.05.006
MLA:
Lanfer, B., et al. "Influences of skull segmentation inaccuracies on EEG source analysis." NeuroImage 62 (2012): 418-31.
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