Reduced plasmalogen concentration as a surrogate marker of oxidative stress in elderly septic patients
Brosche T, Bertsch T, Sieber C, Hoffmann U (2013)
Publication Status: Published
Publication Type: Journal article
Publication year: 2013
Journal
Publisher: ELSEVIER IRELAND LTD
Book Volume: 57
Pages Range: 66-69
Journal Issue: 1
DOI: 10.1016/j.archger.2013.02.007
Abstract
Severe sepsis is reportedly accompanied by oxidative stress with a depletion of antioxidant defense. We estimated plasmalogen vinyl ether bond (PVEB) levels in blood plasma of 20 elderly patients with initial severe sepsis, serving as a sensitive surrogate marker of oxidative stress, and compared them with standard markers, i.e., Acute Physiology and Chronic Health Evaluation (APACHE) II score, C-reactive protein (CRP), creatinine, white blood cell and platelet counts. Patients were included in the study and then blood samples were taken within 24 h of the onset of symptoms of severe sepsis. Twenty sex-and age-matched, healthy individuals were included in the study as controls. We measured plasmalogen-derived hexadecanal dimethyl acetal (16: 0 DMA) in isolated phospholipids from EDTA-plasma using gas chromatography. We found a 55% lower concentration of 16: 0 DMA, corresponding to lower levels of PVEB in the patients' plasma compared to the controls (0.26 +/- 0.15 vs 0.58 +/- 0.13 g/100 g; p < 0.001). In all patients' and non-survivors' samples the 16: 0 DMA levels correlated negatively with plasma CRP values (R-S = -0.48 and R-S = -0.70, respectively; p < 0.05), but not with APACHE II scores or other markers. The observed lower baseline content of PVEB may indicate oxidative stress contributing to the sequlae of sepsis, but did not correlate with the outcome or the severity of illness. Serial measurements are needed to validate PVEB as a marker in sepsis. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
Authors with CRIS profile
Thorolf Brosche
Lehrstuhl für Innere Medizin (Geriatrie)
Cornel Sieber
Lehrstuhl für Innere Medizin (Geriatrie)
Involved external institutions
Germany (DE)How to cite
APA:
Brosche, T., Bertsch, T., Sieber, C., & Hoffmann, U. (2013). Reduced plasmalogen concentration as a surrogate marker of oxidative stress in elderly septic patients. Archives of gerontology and geriatrics, 57(1), 66-69. https://dx.doi.org/10.1016/j.archger.2013.02.007
MLA:
Brosche, Thorolf, et al. "Reduced plasmalogen concentration as a surrogate marker of oxidative stress in elderly septic patients." Archives of gerontology and geriatrics 57.1 (2013): 66-69.
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