Crystal arthritides - gout and calciumpyrophosphate arthritis. Part 1: Epidemiology and pathophysiology

Beitrag in einer Fachzeitschrift


Details zur Publikation

Autorinnen und Autoren: Schlee S, Bollheimer LC, Bertsch T, Sieber C, Haerle P
Zeitschrift: Zeitschrift für Gerontologie und Geriatrie
Verlag: SPRINGER HEIDELBERG
Jahr der Veröffentlichung: 2018
Band: 51
Heftnummer: 4
Seitenbereich: 453-460
ISSN: 0948-6704


Abstract

Gout and calcium pyrophosphate deposition disease (CPPD, pseudogout) are still the most frequent inflammatory arthritides in multimorbid elderly patients. Gout and CPPD are different diseases and based on different pathophysiological principles. Gout is closely associated with the metabolic syndrome and is an independent risk factor for cardiovascular mortality. The prevalence of asymptomatic hyperuricemia is estimated to be 10-20% of adults in industrial nations and prevalence is strongly associated with age. More than 7% of persons aged over 65 years suffer from clinically manifest gout. The underlying pathophysiological principle is an imbalance between the formation and elimination of uric acid. The degradation of the purine bases adenine and guanosine to uric acid is catalysed by xanthine oxidase and genetic polymorphisms and mutations play an important role in absorption and excretion processes. Furthermore, carrier proteins, such as URAT-1 or OAT-4 also have an influence on these processes. An imbalance of the physiological processes results in the solubility product being exceeded, which in consequence leads to crystallization of urate. This induces a cascade of massive inflammatory reactions at the molecular and cellular level with the activation of cytokines. The inflammatory process can be stopped by neutrophil extracellular traps (NETs) that modulate aggregation and degradation of chemokines and cytokines and partitioning of crystallized urate against immune cells. Calcium pyrophosphate dehydrate (CPP) crystals are formed in the cartilage and CPP deposition can be found in 30% of people aged over 80 years. Inorganic pyrophosphate (PPi) is synthesized in chondrocytes and plays an important part in the formation of calcium pyrophosphate crystals. The degradation is catalyzed by inorganic pyrophosphatases. If there is dysregulation of this homeostasis more PPi is produced, which ultimately contributes to the formation of the CPP crystals.


FAU-Autorinnen und Autoren / FAU-Herausgeberinnen und Herausgeber

Sieber, Cornel Prof. Dr.
Lehrstuhl für Innere Medizin (Geriatrie)


Einrichtungen weiterer Autorinnen und Autoren

Katholisches Klinikum Mainz
Krankenhaus Barmherzige Brüder, Academic Teaching Hospital of University Medical Center Regensburg
Paracelsus Medizinische Privatuniversität, Nürnberg
Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen


Zitierweisen

APA:
Schlee, S., Bollheimer, L.C., Bertsch, T., Sieber, C., & Haerle, P. (2018). Crystal arthritides - gout and calciumpyrophosphate arthritis. Part 1: Epidemiology and pathophysiology. Zeitschrift für Gerontologie und Geriatrie, 51(4), 453-460. https://dx.doi.org/10.1007/s00391-017-1197-3

MLA:
Schlee, S., et al. "Crystal arthritides - gout and calciumpyrophosphate arthritis. Part 1: Epidemiology and pathophysiology." Zeitschrift für Gerontologie und Geriatrie 51.4 (2018): 453-460.

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Zuletzt aktualisiert 2018-08-10 um 10:53