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Flow Void Analysis: Multiscale Quantitation and Visualization of Choriocapillaris Alterations in Age-Related Macular Degeneration Using OCT Angiography

Alibhai AY, Moult EM, Rebhun CB, Moreira-Neto C, Novais EA, Lee B, Schottenhamml J, Husvogt L, Maier A, Rosenfeld P, Duker JS, Waheed NK, Fujimoto JG (2017)

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Publication Language: English

Publication Type: Conference contribution

Publication year: 2017

Publisher: ARVO

Book Volume: 58

Pages Range: 817

Edition: 8

Conference Proceedings Title: Investigative Ophthalmology & Visual Science

Event location: Baltimore, MD, USA

URI: https://www5.informatik.uni-erlangen.de/Forschung/Publikationen/2017/Alibhai17-FVA.pdf

Open Access Link: https://iovs.arvojournals.org/article.aspx?articleid=2637739&resultClick=1

Abstract

Purpose : The choriocapillaris (CC) is important in the pathophysiology of age-related macular degeneration (AMD). This study aims to develop optical coherence tomography angiography (OCTA) techniques for quantifying and visualizing CC alterations.

Methods : We developed a novel metric for quantifying CC flow voids (areas of no/low blood flow), as well as a display method: multiscale flow void mapping (MFVM). The metric was tested on normal controls (13 eyes, 9 subjects; 68.2±6.89 y/o), eyes with small drusen (volume<0.02 mm3; 8 eyes, 7 subjects; 69.3±11.22 y/o), large drusen (volume≥0.02 mm3; 6 eyes, 5 subjects; 80.0±5.37 y/o), nascent geographic atrophy (nGA: lesions showing hypertransmission over a linear dimension >125µm but not evident on routine fundus imaging) and/or drusen-associated geographic atrophy (DAGA) (10 eyes, 9 patients; 74.0±7.39 y/o), and geographic atrophy (GA) (6 eyes, 3 subjects; 81.7±9.40 y/o).

Results : There was a trend of increasing CC alteration with age, though this was only significant (p<0.05) in controls (Fig 1A). There was also a trend of increasing CC alteration with disease state (Fig 1C): Mann-Whitney U testing (without Bonferroni correction) showed significantly (p<0.05) different metric values between nGA/DAGA and all other groups, and GA and all other groups (Fig 1D); with Bonferroni correction nGA/DAGA could not be distinguished from large drusen. This analysis did not account for inter-group age variations (Fig 1B), or multiple eyes from the same patient. MFVM was useful for visualizing CC alterations (Fig 2).

Conclusions : Quantitative analysis and MVFM may be useful for monitoring CC alteration as a marker of disease progression.

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How to cite

APA:

Alibhai, A.Y., Moult, E.M., Rebhun, C.B., Moreira-Neto, C., Novais, E.A., Lee, B.,... Fujimoto, J.G. (2017). Flow Void Analysis: Multiscale Quantitation and Visualization of Choriocapillaris Alterations in Age-Related Macular Degeneration Using OCT Angiography. In Investigative Ophthalmology & Visual Science (pp. 817). Baltimore, MD, USA, US: ARVO.

MLA:

Alibhai, A. Yasin, et al. "Flow Void Analysis: Multiscale Quantitation and Visualization of Choriocapillaris Alterations in Age-Related Macular Degeneration Using OCT Angiography." Proceedings of the ARVO Annual Meeting 2017, Baltimore, MD, USA ARVO, 2017. 817.

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