The Definition, Rationale, and Effects of Thresholding in OCT Angiography

Cole ED, Moult EM, Dang S, Choi W, Ploner S, Lee B, Louzada RN, Novais EA, Schottenhamml J, Husvogt L, Maier A, Fujimoto JG, Waheed NK, Duker JS (2017)

Publication Type: Journal article, Original article

Publication year: 2017

Journal

Ophthalmology Retina Elsevier

Book Volume: 1/2017

Pages Range: 435-447

Journal Issue: 5

URI: https://www.sciencedirect.com/science/article/abs/pii/S2468653017300283

DOI: 10.1016/j.oret.2017.01.019

Abstract

Purpose

To examine the definition, rationale, and effects of thresholding in OCT angiography (OCTA).

Design

A theoretical description of OCTA thresholding in combination with qualitative and quantitative analysis of the effects of OCTA thresholding in eyes from a retrospective case series.

Participants

Four eyes were qualitatively examined: 1 from a 27-year-old control, 1 from a 78-year-old exudative age-related macular degeneration (AMD) patient, 1 from a 58-year-old myopic patient, and 1 from a 77-year-old nonexudative AMD patient with geographic atrophy (GA). One eye from a 75-year-old nonexudative AMD patient with GA was quantitatively analyzed.

Main Outcome Measures

A theoretical thresholding model and a qualitative and quantitative description of the dependency of OCTA on thresholding level.

Results

Due to the presence of system noise, OCTA thresholding is a necessary step in forming OCTA images; however, thresholding can complicate the relationship between blood flow and OCTA signal.

Conclusions

Thresholding in OCTA can cause significant artifacts, which should be considered when interpreting and quantifying OCTA images.

Authors with CRIS profile

Stefan Ploner Lehrstuhl für Informatik 5 (Mustererkennung) Julia Schottenhamml Lehrstuhl für Informatik 5 (Mustererkennung) Lennart Husvogt Lehrstuhl für Informatik 5 (Mustererkennung) Andreas Maier Lehrstuhl für Informatik 5 (Mustererkennung)

Involved external institutions

Massachusetts Institute of Technology (MIT)

United States (USA) (US) Tufts Medical Center

United States (USA) (US)

How to cite

APA:

Cole, E.D., Moult, E.M., Dang, S., Choi, W., Ploner, S., Lee, B.,... Duker, J.S. (2017). The Definition, Rationale, and Effects of Thresholding in OCT Angiography. Ophthalmology Retina, 1/2017(5), 435-447. https://doi.org/10.1016/j.oret.2017.01.019

MLA:

Cole, Emily D., et al. "The Definition, Rationale, and Effects of Thresholding in OCT Angiography." Ophthalmology Retina 1/2017.5 (2017): 435-447.

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