Injury-activated glial cells promote wound healing of the adult skin in mice.

Parfejevs V, Debbache J, Shakhova O, Schaefer SM, Glausch M, Wegner M, Suter U, Riekstina U, Werner S, Sommer L (2018)


Publication Language: English

Publication Type: Journal article, Original article

Publication year: 2018

Journal

Publisher: Nature Publishing Group

Book Volume: 9

Pages Range: 236

Journal Issue: 9

DOI: 10.1038/s41467-017-01488-2

Abstract

Cutaneous wound healing is a complex process that aims to re-establish the original structure of the skin and its functions. Among other disorders, peripheral neuropathies are known to severely impair wound healing capabilities of the skin, revealing the importance of skin innervation for proper repair. Here, we report that peripheral glia are crucially involved in this process. Using a mouse model of wound healing, combined with in vivo fate mapping, we show that injury activates peripheral glia by promoting de-differentiation, cell-cycle re-entry and dissemination of the cells into the wound bed. Moreover, injury-activated glia upregulate the expression of many secreted factors previously associated with wound healing and promote myofibroblast differentiation by paracrine modulation of TGF-β signalling. Accordingly, depletion of these cells impairs epithelial proliferation and wound closure through contraction, while their expansion promotes myofibroblast formation. Thus, injury-activated glia and/or their secretome might have therapeutic potential in human wound healing disorders.

Authors with CRIS profile

Involved external institutions

How to cite

APA:

Parfejevs, V., Debbache, J., Shakhova, O., Schaefer, S.M., Glausch, M., Wegner, M.,... Sommer, L. (2018). Injury-activated glial cells promote wound healing of the adult skin in mice. Nature Communications, 9(9), 236. https://dx.doi.org/10.1038/s41467-017-01488-2

MLA:

Parfejevs, Vadims, et al. "Injury-activated glial cells promote wound healing of the adult skin in mice." Nature Communications 9.9 (2018): 236.

BibTeX: Download