Polypoidal Choroidal Vasculopathy on Swept-Source Optical Coherence Tomography Angiography with Variable Interscan Time Analysis

Rebhun CB, Moult EM, Novais EA, Moreira-Neto C, Ploner S, Louzada RN, Lee B, Baumal CR, Fujimoto JG, Duker JS, Waheed NK, Ferrara D (2017)

Publication Type: Journal article

Publication year: 2017

Journal

Translational Vision Science & Technology Association for Research in Vision and Ophthalmology (ARVO)

Publisher: Association for Research in Vision and Ophthalmology Inc.

Book Volume: 6

Journal Issue: 6

URI: https://www5.informatik.uni-erlangen.de/Forschung/Publikationen/2017/Rebhun17-PCV.pdf

DOI: 10.1167/tvst.6.6.4

Abstract

Purpose: To use a novel optical coherence tomography angiography (OCTA) algorithm termed variable interscan time analysis (VISTA) to evaluate relative blood flow speeds in polypoidal choroidal vasculopathy (PCV). Methods: Prospective cross-sectional study enrolling patients with confirmed diagnosis of PCV. OCTA of the retina and choroid was obtained with a prototype swept-source OCT system. The acquired OCT volumes were centered on the branching vascular network (BVN) and polyps as determined by indocyanine-green angiography (ICGA). The relative blood flow speeds were characterized on VISTAOCTA. Results: Seven eyes from seven patients were evaluated. Swept-source OCTA enabled detailed enface visualization of the BVN and polyps in six eyes. VISTA-OCTA revealed variable blood flow speeds in different PCV lesion components of the same eye, with faster flow in the periphery of polyps and slower flow in the center of each polyp, as well as relatively slow flow in BVN when compared with retinal vessels. BVNs demonstrated relatively faster blood flow speeds in the larger trunk vessels and relatively slower speeds in the smaller vessels. Conclusions: Swept-source OCTA identifies polyps in most, but not all, PCV lesions. This limitation that may be related to relatively slow blood flow within the polyp, which may be below the OCTA’s sensitivity. VISTA-OCTA showed heterogeneous blood flow speeds within the polyps, which may indicate turbulent flow in the polyps. Translational Relevance: These results bring relevant insights into disease mechanisms that can account for the variable course of PCV, and can be relevant for diagnosis and management of patients with PCV.

Authors with CRIS profile

Stefan Ploner Lehrstuhl für Informatik 5 (Mustererkennung)

Involved external institutions

Tufts University US United States (USA) (US) Massachusetts Institute of Technology (MIT) US United States (USA) (US)

How to cite

APA:

Rebhun, C.B., Moult, E.M., Novais, E.A., Moreira-Neto, C., Ploner, S., Louzada, R.N.,... Ferrara, D. (2017). Polypoidal Choroidal Vasculopathy on Swept-Source Optical Coherence Tomography Angiography with Variable Interscan Time Analysis. Translational Vision Science & Technology, 6(6). https://dx.doi.org/10.1167/tvst.6.6.4

MLA:

Rebhun, Carl B., et al. "Polypoidal Choroidal Vasculopathy on Swept-Source Optical Coherence Tomography Angiography with Variable Interscan Time Analysis." Translational Vision Science & Technology 6.6 (2017).

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