Hydration mechanism of partially amorphized β-tricalcium phosphate

Journal article
(Original article)

Publication Details

Author(s): Hurle K, Neubauer J, Götz-Neunhoeffer F
Journal: Acta Biomaterialia
Publisher: Elsevier Ltd
Publication year: 2017
Volume: 54
Pages range: 429-440
ISSN: 1742-7061
Language: English


Calcium phosphate cements (CPCs) are applied as bone cements due to their excellent biocompatibility. In the present study, the quantitative phase content development during hydration of partially amorphized β-tricalcium phosphate (β-TCP) within the first 24 h was investigated by in-situ X-ray diffraction (XRD) combined with the G-factor method, an external standard method. The quantity of amorphous phase (ATCP) in the powders was determined by the G-factor method.

The hydration model established for partially amorphized β-TCP indicates that ATCP reacted first, followed by the hydration of a small fraction of crystalline β-TCP starting after some h. Consequently, hydration resulted in biphasic samples composed of calcium deficient hydroxyapatite (CDHA) and crystalline β-TCP. The ratio wt%(CDHA)/wt%(β-TCP) after 24 h hydration was adjustable by the initial ATCP content. The crystallinity of CDHA was nearly independent of the ATCP content. Since the biological degradability of CDHA and β-TCP differ, the degradation performance of the set cements is expected to be adjustable by varying the ATCP content. The present study provided a basic understanding of the hydration mechanism of partially amorphized β-TCP, which is the prerequisite for the development of applicable CPC formulations.

FAU Authors / FAU Editors

Götz-Neunhoeffer, Friedlinde Prof. Dr.
Lehrstuhl für Mineralogie
Hurle, Katrin Dr.
Lehrstuhl für Mineralogie
Neubauer, Jürgen apl. Prof. Dr.
Lehrstuhl für Mineralogie

How to cite

Hurle, K., Neubauer, J., & Götz-Neunhoeffer, F. (2017). Hydration mechanism of partially amorphized β-tricalcium phosphate. Acta Biomaterialia, 54, 429-440. https://dx.doi.org/10.1016/j.actbio.2017.03.013

Hurle, Katrin, Jürgen Neubauer, and Friedlinde Götz-Neunhoeffer. "Hydration mechanism of partially amorphized β-tricalcium phosphate." Acta Biomaterialia 54 (2017): 429-440.


Last updated on 2018-20-12 at 15:08