NOBF4-Functionalized Au-Fe3O4 Nanoheterodimers for Radiation Therapy: Synergy Effect Due to Simultaneous Reactive Oxygen and Nitrogen Species Formation

Beitrag in einer Fachzeitschrift


Details zur Publikation

Autor(en): Klein S, Harreiß C, Menter C, Hümmer J, Distel L, Meyer K, Hock R, Kryschi C
Zeitschrift: ACS Applied Materials and Interfaces
Verlag: AMER CHEMICAL SOC
Jahr der Veröffentlichung: 2018
Band: 10
Heftnummer: 20
Seitenbereich: 17071-17080
ISSN: 1944-8244


Abstract

Snowman-shaped Au-Fe3O4 nanoheterodimers were synthesized by thermal decomposition of iron oleate on presynthesized Au nanoparticles. Subsequently performed ligand exchange with nitrosyl tetrafluoroborate provided water solubility and enabled X-ray-induced NO release. These Au-Fe3O4 nanoheterodimers combine high-Z material with catalytically active Fe3O4 surfaces and, moreover, plasmonic properties with superparamagnetic performance. We could establish synergetic interactions between X-radiation and both the Au and Fe3O4 surfaces, which resulted in the simultaneous production of the nitric oxide radical at the Fe3O4 surface and the superoxide radical at the Au surface. The surface-confined reaction between these radicals generated peroxynitrite. This highly reactive species may cause nitration of mitochondrial proteins and lipid peroxidation and induce DNA strand breaks. Therefore, high concentrations of peroxynitrite are expected to give rise to severe cellular energetic derangements and thereupon entail rapid cell death. As providing a common platform for X-ray-induced formation of the highly superoxide, and peroxynitrite, nitrosyl tetrafluoroborate functionalized Au-Fe3O4 nanosnowmen were shown to exhibit excellent performance as X-ray-enhancing agents in radiation therapy.


FAU-Autoren / FAU-Herausgeber

Distel, Luitpold Prof. Dr.
Strahlenklinik
Harreiß, Christina
Lehrstuhl für Physikalische Chemie I
Hock, Rainer Prof. Dr.
Professur für Kristallographie und Strukturphysik
Hümmer, Julian
Lehrstuhl für Anorganische und Allgemeine Chemie
Klein, Stefanie Dr.
Professur für Physikalische Chemie
Kryschi, Carola Prof. Dr.
Professur für Physikalische Chemie
Menter, Christina
Lehrstuhl für Feststoff- und Grenzflächenverfahrenstechnik
Meyer, Karsten Prof. Dr.
Lehrstuhl für Anorganische und Allgemeine Chemie


Zitierweisen

APA:
Klein, S., Harreiß, C., Menter, C., Hümmer, J., Distel, L., Meyer, K.,... Kryschi, C. (2018). NOBF4-Functionalized Au-Fe3O4 Nanoheterodimers for Radiation Therapy: Synergy Effect Due to Simultaneous Reactive Oxygen and Nitrogen Species Formation. ACS Applied Materials and Interfaces, 10(20), 17071-17080. https://dx.doi.org/10.1021/acsami.8b03660

MLA:
Klein, Stefanie, et al. "NOBF4-Functionalized Au-Fe3O4 Nanoheterodimers for Radiation Therapy: Synergy Effect Due to Simultaneous Reactive Oxygen and Nitrogen Species Formation." ACS Applied Materials and Interfaces 10.20 (2018): 17071-17080.

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Zuletzt aktualisiert 2019-20-03 um 11:38