MS-int@kt: subgroup analysis of an internet-based training on fatigue, quality of life and gait

Gusowski K, Bures AK, Kuld S, Weiland AC, Gawlik A, Streber R, Tallner A, Pfeifer K, Flachenecker P (2018)


Publication Language: English

Publication Type: Conference contribution, Conference Contribution

Publication year: 2018

Conference Proceedings Title: Multiple Sclerosis Journal

Event location: Amsterdam NL

Abstract

Background: Persons with MS (PwMS) benefit from inpatient multidisciplinary rehabilitatoin with regard to fatigue and motor performance. To sustain the effects, an internet-based training program was introduced during rehabilitation and performed for 3 months thereafter. Primary endpoint analysis showed that the internet-based training could maintain the improvements for up to 6 month.

Objectives: In order to determine which PwMS revealed the most pronounced respoonse to therapy, we performed a subgroup analysis by stratifying PwMS according to baseline performance.

Methods: 34 PwMS participated in the training group and 30 in control group. Performance oriented mobility assessment (POMA) for the rist of fall, 10m-walk-test (10MWT) and 2-minute-walking test (2MWT) were measured at the beginning of the inpatient rehabiliation program (T0), at discharge (T1) and 3 month after training (T2), Fatigue (WEImuS) and quality of life (MSIS-29 and EQ-5d) were measured at T0, T1, T2 and 6 month after discharge (T3). Siubgroups were divided in low and high performance (POMA and EQ-5d VAS: median value at T0, 10MWT: 7 sec, 14 steps; 2MWT 168m.

Results The effects of rehabitation on fatigue and quality of life were maintained at T2 and T3 in the training group. Subgroup analysis of omtor performance at T2 showed a significant benefit in 10MWT and POMA in the low performance group, whereas in 2MWT, the high performance subgroup remained highly significant. The EQ-5d VAS demonstrated highly significant changes in the whole training group as well as in the subgroup with low performance.

Discussion: Statistically and clinically meaningful improvements of fatigue, QoL and motor performance were demonstrated after 3 months of internet-based training, with effects being more pronounced in more affected pwMS. An internet-based training program may be effective to maintain the positive effects of inpatient rehabilitation for at least up to 6 months.

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How to cite

APA:

Gusowski, K., Bures, A.-K., Kuld, S., Weiland, A.-C., Gawlik, A., Streber, R.,... Flachenecker, P. (2018). MS-int@kt: subgroup analysis of an internet-based training on fatigue, quality of life and gait. In Multiple Sclerosis Journal. Amsterdam, NL.

MLA:

Gusowski, Klaus, et al. "MS-int@kt: subgroup analysis of an internet-based training on fatigue, quality of life and gait." Proceedings of the Annual RIMS 2018 Conference, Amsterdam 2018.

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