Mutual antagonism between Sox10 and NFIA regulates diversification of glial lineages and glioma subtypes

Glasgow SM, Zhu W, Stolt C, Huang TW, Chen F, Loturco JJ, Neul JL, Wegner M, Mohila C, Deneen B (2014)


Publication Type: Journal article

Publication year: 2014

Journal

Publisher: Nature Publishing Group

Book Volume: 17

Pages Range: 1322-9

Journal Issue: 10

DOI: 10.1038/nn.3790

Abstract

Lineage progression and diversification is regulated by the coordinated action of unique sets of transcription factors. Oligodendrocytes (OL) and astrocytes (AS) comprise the glial sub-lineages in the CNS, and the manner in which their associated regulatory factors orchestrate lineage diversification during development and disease remains an open question. Sox10 and NFIA are key transcriptional regulators of gliogenesis associated with OL and AS. We found that NFIA inhibited Sox10 induction of OL differentiation through direct association and antagonism of its function. Conversely, we found that Sox10 antagonized NFIA function and suppressed AS differentiation in mouse and chick systems. Using this developmental paradigm as a model for glioma, we found that this relationship similarly regulated the generation of glioma subtypes. Our results describe the antagonistic relationship between Sox10 and NFIA that regulates the balance of OL and AS fate during development and demonstrate for the first time, to the best of our knowledge, that the transcriptional processes governing glial sub-lineage diversification oversee the generation of glioma subtypes.

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How to cite

APA:

Glasgow, S.M., Zhu, W., Stolt, C., Huang, T.-W., Chen, F., Loturco, J.J.,... Deneen, B. (2014). Mutual antagonism between Sox10 and NFIA regulates diversification of glial lineages and glioma subtypes. Nature Neuroscience, 17(10), 1322-9. https://dx.doi.org/10.1038/nn.3790

MLA:

Glasgow, Stacey M., et al. "Mutual antagonism between Sox10 and NFIA regulates diversification of glial lineages and glioma subtypes." Nature Neuroscience 17.10 (2014): 1322-9.

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