Dishevelled Paralogs in Vertebrate Development: Redundant or Distinct?

Beitrag in einer Fachzeitschrift
(Review-Artikel)


Details zur Publikation

Autor(en): Gentzel M, Schambony A
Zeitschrift: Frontiers in cell and developmental biology
Jahr der Veröffentlichung: 2017
Band: 5
Seitenbereich: 59
ISSN: 2296-634X


Abstract


Dishevelled (DVL) proteins are highly conserved in the animal kingdom and are important key players in β-Catenin-dependent and -independent Wnt signaling pathways. Vertebrate genomes typically comprise three DVL genes, DVL1, DVL2, and DVL3. Expression patterns and developmental functions of the three vertebrate DVL proteins however, are only partially redundant in any given species. Moreover, expression and function of DVL isoforms have diverged between different vertebrate species. All DVL proteins share basic functionality in Wnt signal transduction. Additional, paralog-specific interactions and functions combined with context-dependent availability of DVL isoforms may play a central role in defining Wnt signaling specificity and add selectivity toward distinct downstream pathways. In this review, we recapitulate briefly cellular functions of DVL paralogs, their role in vertebrate embryonic development and congenital disease.



FAU-Autoren / FAU-Herausgeber

Schambony, Alexandra PD Dr.
Lehrstuhl für Entwicklungsbiologie


Autor(en) der externen Einrichtung(en)
Max-Planck-Institut für molekulare Zellbiologie und Genetik / Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG)


Zitierweisen

APA:
Gentzel, M., & Schambony, A. (2017). Dishevelled Paralogs in Vertebrate Development: Redundant or Distinct? Frontiers in cell and developmental biology, 5, 59. https://dx.doi.org/10.3389/fcell.2017.00059

MLA:
Gentzel, Marc, and Alexandra Schambony. "Dishevelled Paralogs in Vertebrate Development: Redundant or Distinct?" Frontiers in cell and developmental biology 5 (2017): 59.

BibTeX: 

Zuletzt aktualisiert 2018-18-10 um 03:40