Dishevelled Paralogs in Vertebrate Development: Redundant or Distinct?
Gentzel M, Schambony A (2017)
Publication Status: Published
Publication Type: Journal article, Review article
Publication year: 2017
Journal
Book Volume: 5
Pages Range: 59
Open Access Link: http://journal.frontiersin.org/article/10.3389/fcell.2017.00059/full
Abstract
Dishevelled (DVL) proteins are highly conserved in the animal kingdom and are important key players in β-Catenin-dependent and -independent Wnt signaling pathways. Vertebrate genomes typically comprise three DVL genes, DVL1, DVL2, and DVL3. Expression patterns and developmental functions of the three vertebrate DVL proteins however, are only partially redundant in any given species. Moreover, expression and function of DVL isoforms have diverged between different vertebrate species. All DVL proteins share basic functionality in Wnt signal transduction. Additional, paralog-specific interactions and functions combined with context-dependent availability of DVL isoforms may play a central role in defining Wnt signaling specificity and add selectivity toward distinct downstream pathways. In this review, we recapitulate briefly cellular functions of DVL paralogs, their role in vertebrate embryonic development and congenital disease.
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Germany (DE)How to cite
APA:
Gentzel, M., & Schambony, A. (2017). Dishevelled Paralogs in Vertebrate Development: Redundant or Distinct? Frontiers in Cell and Developmental Biology, 5, 59. https://dx.doi.org/10.3389/fcell.2017.00059
MLA:
Gentzel, Marc, and Alexandra Schambony. "Dishevelled Paralogs in Vertebrate Development: Redundant or Distinct?" Frontiers in Cell and Developmental Biology 5 (2017): 59.
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