Pechstein J, Schulze-Luehrmann J, Lührmann A (2017)
Publication Type: Journal article
Publication year: 2017
DOI: 10.1016/j.ijmm.2017.09.010
Coxiella burnetii is an obligate intracellular and airborne pathogen which can cause the zoonotic disease Q fever. After inhalation of contaminated aerosols alveolar macrophages are taking up C. burnetii into a phagosome. This phagosome matures to a very large vacuole called the C. burnetii-containing vacuole (CCV). Host endogenous and bacterial driven processes lead to the biogenesis of this unusual compartment, which resembles partially a phagolysosome. However, there are several important differences to the classical phagolysosome, which are crucial for the ability of C. burnetii to replicate intracellularly and depend on a functional type IV secretion system (T4SS). The T4SS delivers effector proteins into the host cell cytoplasm to redirect intracellular processes, leading to the establishment of a microenvironment allowing bacterial replication. This article summarizes the current knowledge of the microenvironment permissive for C. burnetii replication.
APA:
Pechstein, J., Schulze-Luehrmann, J., & Lührmann, A. (2017). Coxiella burnetiias a useful tool to investigate bacteria-friendly host cell compartments. International Journal of Medical Microbiology. https://dx.doi.org/10.1016/j.ijmm.2017.09.010
MLA:
Pechstein, Julian, Jan Schulze-Luehrmann, and Anja Lührmann. "Coxiella burnetiias a useful tool to investigate bacteria-friendly host cell compartments." International Journal of Medical Microbiology (2017).
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