Drug release from collagen matrices including an evolving microstructure

Ray N, van Noorden T, Radu AF, Friess W, Knabner P (2013)


Publication Status: Published

Publication Type: Journal article, Original article

Publication year: 2013

Journal

Publisher: Wiley-VCH Verlag

Book Volume: 93

Pages Range: 811-822

URI: https://www1.am.uni-erlangen.de/research/publications/Jahr_2013/2013_RayNoordenRaduFriessKn_DrugReleaseFromCollMatIncludAnEvolvingMicrostruct

DOI: 10.1002/zamm.201200196

Abstract

Biodegradable collagen matrices have become a promising alternative to traditional drug delivery systems. The relevant mechanisms in controlled drug release are the diffusion of water into the collagen matrix, the swelling of the matrix coming along with drug release, and enzymatic degradation of the matrix with additional simultaneous drug release. These phenomena have been extensively studied in the past experimentally, via numerical simulations as well as analytically. However, a rigorous derivation of the macroscopic model description, which includes the evolving microstructure due to the degradation process, is still lacking. Since matrix degradation leads to the release of physically entrapped active agent, a good understanding of these phenomena is very important. We present such a derivation using formal twoscale asymptotic expansion in a level set framework and complete our results with numerical simulations in comparison with experimental data. Biodegradable collagen matrices have become a~promising alternative to traditional drug delivery systems. The relevant mechanisms in controlled drug release are the diffusion of water into the collagen matrix, the swelling of the matrix coming along with drug release, and enzymatic degradation of the matrix with additional simultaneous drug release. These phenomena have been extensively studied in the past experimentally, via numerical simulations as well as analytically. However, a rigorous derivation of the macroscopic model description, which includes the evolving microstructure due to the degradation process, is still lacking. Since matrix degradation leads to the release of physically entrapped active agent, a~good understanding of these phenomena is very important. The authors present such a~derivation using formal twoscale asymptotic expansion in a~level set framework and complete their results with numerical simulations in comparison with experimental data. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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How to cite

APA:

Ray, N., van Noorden, T., Radu, A.F., Friess, W., & Knabner, P. (2013). Drug release from collagen matrices including an evolving microstructure. ZAMM - Zeitschrift für angewandte Mathematik und Mechanik, 93, 811-822. https://dx.doi.org/10.1002/zamm.201200196

MLA:

Ray, Nadja, et al. "Drug release from collagen matrices including an evolving microstructure." ZAMM - Zeitschrift für angewandte Mathematik und Mechanik 93 (2013): 811-822.

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