Ephrin-B1 controls the columnar distribution of cortical pyramidal neurons by restricting their tangential migration
Dimidschstein J, Passante L, Dufour A, Van Den Ameele J, Tiberi L, Hrechdakian T, Adams R, Klein R, Lie DC, Jossin Y, Vanderhaeghen P (2013)
Publication Type: Journal article
Publication year: 2013
Journal
Publisher: Elsevier (Cell Press)
Book Volume: 79
Pages Range: 1123-35
Journal Issue: 6
DOI: 10.1016/j.neuron.2013.07.015
Abstract
Neurons of the cerebral cortex are organized in layers and columns. Unlike laminar patterning, the mechanisms underlying columnar organization remain largely unexplored. Here, we show that ephrin-B1 plays a key role in this process through the control of nonradial steps of migration of pyramidal neurons. In vivo gain of function of ephrin-B1 resulted in a reduction of tangential motility of pyramidal neurons, leading to abnormal neuronal clustering. Conversely, following genetic disruption of ephrin-B1, cortical neurons displayed a wider lateral dispersion, resulting in enlarged ontogenic columns. Dynamic analyses revealed that ephrin-B1 controls the lateral spread of pyramidal neurons by limiting neurite extension and tangential migration during the multipolar phase. Furthermore, we identified P-Rex1, a guanine-exchange factor for Rac3, as a downstream ephrin-B1 effector required to control migration during the multipolar phase. Our results demonstrate that ephrin-B1 inhibits nonradial migration of pyramidal neurons, thereby controlling the pattern of cortical columns.
Authors with CRIS profile
Involved external institutions
Université libre de Bruxelles (ULB) / Free University of Brussels
Belgium (BE)
Max-Planck-Institut für molekulare Biomedizin / Max Planck Institute for Molecular Biomedicine
Germany (DE)
Max-Planck-Institut für Neurobiologie / Max Planck Institute of Neurobiology
Germany (DE)
Fred Hutchinson Cancer Research Center
Canada (CA)
Belgium (BE)
Max-Planck-Institut für molekulare Biomedizin / Max Planck Institute for Molecular Biomedicine
Germany (DE)
Max-Planck-Institut für Neurobiologie / Max Planck Institute of Neurobiology
Germany (DE)
Fred Hutchinson Cancer Research Center
Canada (CA)
How to cite
APA:
Dimidschstein, J., Passante, L., Dufour, A., Van Den Ameele, J., Tiberi, L., Hrechdakian, T.,... Vanderhaeghen, P. (2013). Ephrin-B1 controls the columnar distribution of cortical pyramidal neurons by restricting their tangential migration. Neuron, 79(6), 1123-35. https://dx.doi.org/10.1016/j.neuron.2013.07.015
MLA:
Dimidschstein, Jordane, et al. "Ephrin-B1 controls the columnar distribution of cortical pyramidal neurons by restricting their tangential migration." Neuron 79.6 (2013): 1123-35.
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