Strategies for the chemical and biological functionalization of scaffolds for cardiac tissue engineering: A review

Tallawi M, Rosellini E, Barbani N, Cascone MG, Rai R, Saint-Pierre G, Boccaccini AR (2015)

Publication Status: Published

Publication Type: Journal article, Review article

Publication year: 2015

Journal

Journal of the Royal Society Interface

Book Volume: 12

Article Number: 0254

Journal Issue: 108

DOI: 10.1098/rsif.2015.0254

Abstract

The development of biomaterials for cardiac tissue engineering (CTE) is challenging, primarily owing to the requirement of achieving a surface with favourable characteristics that enhances cell attachment and maturation. The biomaterial surface plays a crucial role as it forms the interface between the scaffold (or cardiac patch) and the cells. In the field of CTE, synthetic polymers (polyglycerol sebacate, polyethylene glycol, polyglycolic acid, poly-L-lactide, polyvinyl alcohol, polycaprolactone, polyurethanes and poly(N-isopropylacrylamide)) have been proven to exhibit suitable biodegradable and mechanical properties. Despite the fact that they show the required biocompatible behaviour, most synthetic polymers exhibit poor cell attachment capability. These synthetic polymers are mostly hydrophobic and lack cell recognition sites, limiting their application. Therefore, biofunctionalization of these biomaterials to enhance cell attachment and cell material interaction is being widely investigated. There are numerous approaches for functionalizing a material, which can be classified as mechanical, physical, chemical and biological. In this review, recent studies reported in the literature to functionalize scaffolds in the context of CTE, are discussed. Surface, morphological, chemical and biological modifications are introduced and the results of novel promising strategies and techniques are discussed.

Authors with CRIS profile

Marwa Tallawi Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Ranjana Rai Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Aldo Boccaccini Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)

Involved external institutions

University of Pisa / Università di Pisa (UniPi) IT Italy (IT) Tecnologías Avanzadas Inspiralia, S.L. ES Spain (ES)

How to cite

APA:

Tallawi, M., Rosellini, E., Barbani, N., Cascone, M.G., Rai, R., Saint-Pierre, G., & Boccaccini, A.R. (2015). Strategies for the chemical and biological functionalization of scaffolds for cardiac tissue engineering: A review. Journal of the Royal Society Interface, 12(108). https://dx.doi.org/10.1098/rsif.2015.0254

MLA:

Tallawi, Marwa, et al. "Strategies for the chemical and biological functionalization of scaffolds for cardiac tissue engineering: A review." Journal of the Royal Society Interface 12.108 (2015).

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