Angiogenic effects of ionic dissolution products released from a boron-doped 45S5 bioactive glass
Haro Durand LA, Vargas GE, Romero NM, Vera-Mesones R, Porto-Lopez JM, Boccaccini AR, Zago MP, Baldi A, Gorustovich A (2015)
Publication Status: Published
Publication Type: Journal article
Publication year: 2015
Journal
Book Volume: 3
Pages Range: 1142-1148
Journal Issue: 6
DOI: 10.1039/c4tb01840k
Abstract
In regenerative medicine of vascularized tissues, there is a great interest in the use of biomaterials that are able to stimulate angiogenesis, a process necessary for rapid revascularization to allow the transport and exchange of oxygen, nutrients, growth factors and cells that take part in tissue repair and/or regeneration. An increasing number of publications have shown that bioactive glasses stimulate angiogenesis. Because it has been established that boron (B) may play a role in angiogenesis, the aim of this study was to assess the in vivo angiogenic effects of the ionic dissolution products that from a bioactive glass (BG) in the 45S5 system doped with 2 wt% B2O3 (45S5.2B). The pro-angiogenic capacity of 45S5.2B BG was assessed on the vasculature of the embryonic quail chorioallantoic membrane (CAM). Ionic dissolution products from 45S5.2B BG increased angiogenesis. This is quantitatively evidenced by the greater expression of integrin alpha(v)beta(3) and higher vascular density in the embryonic quail CAM. The response observed at 2 and 5 days post-treatment was equivalent to that achieved by applying 10 mu g mL(-1) of basic fibroblast growth factor. These results show that the ionic dissolution products released from the bioactive glass 45S5.2B stimulate angiogenesis in vivo. The effects observed are attributed to the presence the ionic dissolution products, which contained 160 +/- 10 mu M borate.
Authors with CRIS profile
Involved external institutions
Instituto de Tecnologías y Ciencias de la Ingeniería "Hilario Fernández Long" (INTECIN)
Argentina (AR)
Experimental Medicine and Biology Institute / Instituto de Biología y Medicina Experimental (IByME)
Argentina (AR)
Instituto de Patología Experimental (IPE)
Argentina (AR)
Instituto de Investigaciones en Ciencia y Tecnología de Materiales (INTEMA)
Argentina (AR)
Universidad Nacional de Salta
Argentina (AR)
Argentina (AR)
Experimental Medicine and Biology Institute / Instituto de Biología y Medicina Experimental (IByME)
Argentina (AR)
Instituto de Patología Experimental (IPE)
Argentina (AR)
Instituto de Investigaciones en Ciencia y Tecnología de Materiales (INTEMA)
Argentina (AR)
Universidad Nacional de Salta
Argentina (AR)
How to cite
APA:
Haro Durand, L.A., Vargas, G.E., Romero, N.M., Vera-Mesones, R., Porto-Lopez, J.M., Boccaccini, A.R.,... Gorustovich, A. (2015). Angiogenic effects of ionic dissolution products released from a boron-doped 45S5 bioactive glass. Journal of Materials Chemistry B, 3(6), 1142-1148. https://dx.doi.org/10.1039/c4tb01840k
MLA:
Haro Durand, Luis A., et al. "Angiogenic effects of ionic dissolution products released from a boron-doped 45S5 bioactive glass." Journal of Materials Chemistry B 3.6 (2015): 1142-1148.
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