Coexistence of dilute and densely packed domains of ligand-receptor bonds in membrane adhesion
Schmidt D, Bihr T, Seifert U, Smith AS (2012)
Publication Language: English
Publication Status: Published
Publication Type: Journal article, Original article
Publication year: 2012
Journal
Publisher: EPL ASSOCIATION, EUROPEAN PHYSICAL SOCIETY
Book Volume: 99
Article Number: 38003
Journal Issue: 3
URI: http://iopscience.iop.org/article/10.1209/0295-5075/99/38003/meta
DOI: 10.1209/0295-5075/99/38003
Abstract
We analyze the stability of micro-domains of ligand-receptor bonds that mediate the adhesion of biological model membranes. After evaluating the effects of membrane fluctuations on the binding affinity of a single bond, we characterize the organization of bonds within the domains by theoretical means. In a large range of parameters, we find the commonly suggested dense packing to be separated by a free energy barrier from a regime in which bonds are sparsely distributed. If bonds are mobile, a coexistence of the two regimes should emerge, which agrees with recent experimental observations. Copyright (C) EPLA, 2012
Authors with CRIS profile
Additional Organisation(s)
Related research project(s)
Involved external institutions
Germany (DE)How to cite
APA:
Schmidt, D., Bihr, T., Seifert, U., & Smith, A.-S. (2012). Coexistence of dilute and densely packed domains of ligand-receptor bonds in membrane adhesion. EPL - Europhysics Letters, 99(3). https://dx.doi.org/10.1209/0295-5075/99/38003
MLA:
Schmidt, Daniel, et al. "Coexistence of dilute and densely packed domains of ligand-receptor bonds in membrane adhesion." EPL - Europhysics Letters 99.3 (2012).
BibTeX: Download