The Formation of Calcified Nanospherites during Micropetrosis Represents a Unique Mineralization Mechanism in Aged Human Bone

Beitrag in einer Fachzeitschrift
(Originalarbeit)


Details zur Publikation

Autorinnen und Autoren: Milovanovic P, Zimmermann EA, Scheidt AV, Hoffmann B, Sarau G, Yorgan T, Schweizer M, Amling M, Christiansen S, Busse B
Zeitschrift: Small
Verlag: Wiley-VCH Verlag
Jahr der Veröffentlichung: 2017
Band: 13
Heftnummer: 3
ISSN: 1613-6829
eISSN: 1613-6810


Abstract


Osteocytes—the central regulators of bone remodeling—are enclosed in a network of microcavities (lacunae) and nanocanals (canaliculi) pervading the mineralized bone. In a hitherto obscure process related to aging and disease, local plugs in the lacuno-canalicular network disrupt cellular communication and impede bone homeostasis. By utilizing a suite of high-resolution imaging and physics-based techniques, it is shown here that the local plugs develop by accumulation and fusion of calcified nanospherites in lacunae and canaliculi (micropetrosis). Two distinctive nanospherites phenotypes are found to originate from different osteocytic elements. A substantial deviation in the spherites' composition in comparison to mineralized bone further suggests a mineralization process unlike regular bone mineralization. Clearly, mineralization of osteocyte lacunae qualifies as a strong marker for degrading bone material quality in skeletal aging. The understanding of micropetrosis may guide future therapeutics toward preserving osteocyte viability to maintain mechanical competence and fracture resistance of bone in elderly individuals.



FAU-Autorinnen und Autoren / FAU-Herausgeberinnen und Herausgeber

Hoffmann, Björn
Lehrstuhl für Experimentalphysik (Optik)


Zusätzliche Organisationseinheit(en)
Graduiertenkolleg 1896/2 In situ Mikroskopie mit Elektronen, Röntgenstrahlen und Rastersonden
Interdisziplinäres Zentrum, Center for Nanoanalysis and Electron Microscopy (CENEM)


Einrichtungen weiterer Autorinnen und Autoren

Max-Planck-Institut für die Physik des Lichts (MPL) / Max Planck Institute for the Science of Light
Universitätsklinikum Hamburg-Eppendorf (UKE)


Zitierweisen

APA:
Milovanovic, P., Zimmermann, E.A., Scheidt, A.V., Hoffmann, B., Sarau, G., Yorgan, T.,... Busse, B. (2017). The Formation of Calcified Nanospherites during Micropetrosis Represents a Unique Mineralization Mechanism in Aged Human Bone. Small, 13(3). https://dx.doi.org/10.1002/smll.201602215

MLA:
Milovanovic, Petar, et al. "The Formation of Calcified Nanospherites during Micropetrosis Represents a Unique Mineralization Mechanism in Aged Human Bone." Small 13.3 (2017).

BibTeX: 

Zuletzt aktualisiert 2019-06-08 um 09:07