ROR-Family Receptor Tyrosine Kinases.

Beitrag in einer Fachzeitschrift

Details zur Publikation

Autorinnen und Autoren: Stricker S, Rauschenberger V, Schambony A
Zeitschrift: Current Topics in Developmental Biology
Jahr der Veröffentlichung: 2017
Band: 123
Seitenbereich: 105-142
ISSN: 0070-2153


ROR-family receptor tyrosine kinases form a small subfamily of receptor tyrosine kinases (RTKs), characterized by a conserved, unique domain architecture. ROR RTKs are evolutionary conserved throughout the animal kingdom and act as alternative receptors and coreceptors of WNT ligands. The intracellular signaling cascades activated downstream of ROR receptors are diverse, including but not limited to ROR-Frizzled-mediated activation of planar cell polarity signaling, RTK-like signaling, and antagonistic regulation of WNT/β-Catenin signaling. In line with their diverse repertoire of signaling functions, ROR receptors are involved in the regulation of multiple processes in embryonic development such as development of the axial and paraxial mesoderm, the nervous system and the neural crest, the axial and appendicular skeleton, and the kidney. In humans, mutations in the ROR2 gene cause two distinct developmental syndromes, recessive Robinow syndrome (RRS; MIM 268310) and dominant brachydactyly type B1 (BDB1; MIM 113000). In Robinow syndrome patients and animal models, the development of multiple organs is affected, whereas BDB1 results only in shortening of the distal phalanges of fingers and toes, reflecting the diversity of functions and signaling activities of ROR-family RTKs. In this chapter, we give an overview on ROR receptor structure and function. We discuss their signaling functions and role in vertebrate embryonic development with a focus on those developmental processes that are affected by mutations in the ROR2 gene in human patients.

FAU-Autorinnen und Autoren / FAU-Herausgeberinnen und Herausgeber

Rauschenberger, Verena
Lehrstuhl für Entwicklungsbiologie
Schambony, Alexandra Prof. Dr.
Lehrstuhl für Entwicklungsbiologie

Einrichtungen weiterer Autorinnen und Autoren

Freie Universität Berlin


Stricker, S., Rauschenberger, V., & Schambony, A. (2017). ROR-Family Receptor Tyrosine Kinases. Current Topics in Developmental Biology, 123, 105-142.

Stricker, Sigmar, Verena Rauschenberger, and Alexandra Schambony. "ROR-Family Receptor Tyrosine Kinases." Current Topics in Developmental Biology 123 (2017): 105-142.


Zuletzt aktualisiert 2018-08-08 um 14:38