Minimal surface scaffold designs for tissue engineering

Kapfer S, Hyde ST, Mecke K, Arns CH, Schröder-Turk G (2011)

Publication Status: Published

Publication Type: Journal article

Publication year: 2011

Journal

Biomaterials Elsevier

Publisher: ELSEVIER SCI LTD

Book Volume: 32

Pages Range: 6875-6882

Journal Issue: 29

DOI: 10.1016/j.biomaterials.2011.06.012

Abstract

Triply-periodic minimal surfaces are shown to be a more versatile source of biomorphic scaffold designs than currently reported in the tissue engineering literature. A scaffold architecture with sheetlike morphology based on minimal surfaces is discussed, with significant structural and mechanical advantages over conventional designs. These sheet solids are porous solids obtained by inflation of cubic minimal surfaces to sheets of finite thickness, as opposed to the conventional network solids where the minimal surface forms the solid/void interface. Using a finite-element approach, the mechanical stiffness of sheet solids is shown to exceed that of conventional network solids for a wide range of volume fractions and material parameters. We further discuss structure property relationships for mechanical properties useful for custom-designed fabrication by rapid prototyping. Transport properties of the scaffolds are analyzed using Lattice-Boltzmann computations of the fluid permeability. The large number of different minimal surfaces, each of which can be realized as sheet or network solids and at different volume fractions, provides design flexibility essential for the optimization of competing design targets. (C) 2011 Elsevier Ltd. All rights reserved.

Authors with CRIS profile

Sebastian Kapfer Lehrstuhl für Theoretische Physik Klaus Mecke Lehrstuhl für Theoretische Physik Gerd Schröder-Turk Lehrstuhl für Theoretische Physik

Additional Organisation(s)

Exzellenz-Cluster Engineering of Advanced Materials

Involved external institutions

University of New South Wales (UNSW) AU Australia (AU) Australian National University (ANU) AU Australia (AU)

How to cite

APA:

Kapfer, S., Hyde, S.T., Mecke, K., Arns, C.H., & Schröder-Turk, G. (2011). Minimal surface scaffold designs for tissue engineering. Biomaterials, 32(29), 6875-6882. https://dx.doi.org/10.1016/j.biomaterials.2011.06.012

MLA:

Kapfer, Sebastian, et al. "Minimal surface scaffold designs for tissue engineering." Biomaterials 32.29 (2011): 6875-6882.

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