Mechanisms of Autoantibody-Induced Pathology.

Beitrag in einer Fachzeitschrift

Details zur Publikation

Autor(en): Ludwig RJ, Vanhoorelbeke K, Leypoldt F, Kaya Z, Bieber K, Mclachlan SM, Komorowski L, Luo J, Cabral-Marques O, Hammers CM, Lindstrom JM, Lamprecht P, Fischer A, Riemekasten G, Tersteeg C, Sondermann P, Rapoport B, Wandinger KP, Probst C, El Beidaq A, Schmidt E, Verkman A, Manz RA, Nimmerjahn F
Zeitschrift: Frontiers in Immunology
Jahr der Veröffentlichung: 2017
Band: 8
Seitenbereich: 603
ISSN: 1664-3224


Autoantibodies are frequently observed in healthy individuals. In a minority of these individuals, they lead to manifestation of autoimmune diseases, such as rheumatoid arthritis or Graves' disease. Overall, more than 2.5% of the population is affected by autoantibody-driven autoimmune disease. Pathways leading to autoantibody-induced pathology greatly differ among different diseases, and autoantibodies directed against the same antigen, depending on the targeted epitope, can have diverse effects. To foster knowledge in autoantibody-induced pathology and to encourage development of urgently needed novel therapeutic strategies, we here categorized autoantibodies according to their effects. According to our algorithm, autoantibodies can be classified into the following categories: (1) mimic receptor stimulation, (2) blocking of neural transmission, (3) induction of altered signaling, triggering uncontrolled (4) microthrombosis, (5) cell lysis, (6) neutrophil activation, and (7) induction of inflammation. These mechanisms in relation to disease, as well as principles of autoantibody generation and detection, are reviewed herein.

FAU-Autoren / FAU-Herausgeber

Nimmerjahn, Falk Prof. Dr.
Lehrstuhl für Genetik

Autor(en) der externen Einrichtung(en)
EUROIMMUN Medizinische Labordiagnostika AG
Ruprecht-Karls-Universität Heidelberg
SuppreMol GmbH
The Interdisciplinary Research Facility Life Sciences
Universitätsklinikum Schleswig-Holstein (UKSH)
Universität zu Lübeck
University of California Los Angeles (UCLA)
University of California San Francisco (UCSF)
University of Pennsylvania


Ludwig, R.J., Vanhoorelbeke, K., Leypoldt, F., Kaya, Z., Bieber, K., Mclachlan, S.M.,... Nimmerjahn, F. (2017). Mechanisms of Autoantibody-Induced Pathology. Frontiers in Immunology, 8, 603.

Ludwig, Ralf J., et al. "Mechanisms of Autoantibody-Induced Pathology." Frontiers in Immunology 8 (2017): 603.


Zuletzt aktualisiert 2019-17-04 um 08:17