DC subset-specific induction of T cell responses upon antigen uptake via Fcγ receptors in vivo.

Beitrag in einer Fachzeitschrift


Details zur Publikation

Autor(en): Lehmann C, Baranska A, Heidkamp G, Heger L, Neubert K, Luehr JJ, Hoffmann A, Reimer K, Brückner C, Beck S, Seeling M, Kießling M, Soulat D, Krug AB, Ravetch JV, Leusen JHW, Nimmerjahn F, Dudziak D
Zeitschrift: Journal of Experimental Medicine
Jahr der Veröffentlichung: 2017
Band: 214
Heftnummer: 5
Seitenbereich: 1509-1528
ISSN: 1540-9538


Abstract


Dendritic cells (DCs) are efficient antigen-presenting cells equipped with various cell surface receptors for the direct or indirect recognition of pathogenic microorganisms. Interestingly, not much is known about the specific expression pattern and function of the individual activating and inhibitory Fcγ receptors (FcγRs) on splenic DC subsets in vivo and how they contribute to the initiation of T cell responses. By targeting antigens to select activating and the inhibitory FcγR in vivo, we show that antigen uptake under steady-state conditions results in a short-term expansion of antigen-specific T cells, whereas under inflammatory conditions especially, the activating FcγRIV is able to induce superior CD4(+) and CD8(+) T cell responses. Of note, this effect was independent of FcγR intrinsic activating signaling pathways. Moreover, despite the expression of FcγRIV on both conventional splenic DC subsets, the induction of CD8(+) T cell responses was largely dependent on CD11c(+)CD8(+) DCs, whereas CD11c(+)CD8(-) DCs were critical for priming CD4(+) T cell responses.



FAU-Autoren / FAU-Herausgeber

Brückner, Christin
Lehrstuhl für Genetik
Dudziak, Diana Prof. Dr.
Professur für die Biologie Dendritischer Zellen
Heger, Lukas Dr.
Interdisziplinäres Zentrum für Klinische Forschung IZKF Prof.Dr.Kalden Medizinische Klinik 3
Heidkamp, Gordon Dr. rer. nat.
Hautklinik
Hoffmann, Alana
Professur für Molekulare Neurologie
Kießling, Melissa
Lehrstuhl für Genetik
Lehmann, Christian Dr. rer. nat.
Hautklinik
Nimmerjahn, Falk Prof. Dr.
Lehrstuhl für Genetik
Reimer, Katharina
Professur für die Biologie Dendritischer Zellen
Seeling, Michaela Dr.
Department Biologie


Autor(en) der externen Einrichtung(en)
Ludwig-Maximilians-Universität (LMU)
Rockefeller University
University Medical Centre Utrecht (UMC Utrecht)


Zitierweisen

APA:
Lehmann, C., Baranska, A., Heidkamp, G., Heger, L., Neubert, K., Luehr, J.J.,... Dudziak, D. (2017). DC subset-specific induction of T cell responses upon antigen uptake via Fcγ receptors in vivo. Journal of Experimental Medicine, 214(5), 1509-1528. https://dx.doi.org/10.1084/jem.20160951

MLA:
Lehmann, Christian, et al. "DC subset-specific induction of T cell responses upon antigen uptake via Fcγ receptors in vivo." Journal of Experimental Medicine 214.5 (2017): 1509-1528.

BibTeX: 

Zuletzt aktualisiert 2018-08-08 um 13:24