Structural Characterization of Lecithin-Stabilized Tetracosane Lipid Nanoparticles. Part II: Suspensions

Journal article
(Original article)

Publication Details

Author(s): Schmiele M, Busch S, Morhenn H, Schindler T, Schmutzler T, Schweins R, Lindner P, Boesecke P, Westermann M, Steiniger F, Funari SS, Unruh T
Journal: Journal of Physical Chemistry B
Publisher: American Chemical Society
Publication year: 2016
Volume: 120
Journal issue: 24
Pages range: 5513-5526
ISSN: 1520-6106
eISSN: 1520-5207


Using photon correlation spectroscopy, transmission electron microscopy, microcalorimetry, wide-angle X-ray scattering (WAXS), and small-angle X-ray and neutron scattering (SAXS, SANS), the structure of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC)-stabilized colloidal tetracosane suspensions was studied from the molecular level to the microscopic scale as a function of the temperature. The platelike nanocrystals exhibit for tetracosane an unusual orthorhombic low-temperature crystal structure. The corresponding WAXS pattern can be reproduced with a predicted orthorhombic unit cell (space group Pca2), which usually occurs only for much longer even-numbered n-alkanes. Special emphasis was placed on the structure of the DMPC stabilizer layer covering the nanocrystals. Their structure was investigated by SAXS and SANS, using suspensions with different neutron scattering contrasts. As for the emulsions in Part I, the crystallized nanoparticles are covered by a DMPC monolayer. Their significant smaller thickness of 10.5 å (for the emulsions in Part I: 16 å) could be related to a more tilted orientation of the DMPC molecules to cover the expanded surface of the crystallized nanoparticles.

FAU Authors / FAU Editors

Schindler, Torben
Professur für Nanomaterialcharakterisierung (Streumethoden)
Schmiele, Martin
Professur für Nanomaterialcharakterisierung (Streumethoden)
Schmutzler, Tilo
Professur für Nanomaterialcharakterisierung (Streumethoden)
Unruh, Tobias Prof. Dr.
Professur für Nanomaterialcharakterisierung (Streumethoden)

Additional Organisation
Graduiertenkolleg 1896/2 In situ Mikroskopie mit Elektronen, Röntgenstrahlen und Rastersonden
Exzellenz-Cluster Engineering of Advanced Materials
Interdisziplinäres Zentrum, Center for Nanoanalysis and Electron Microscopy (CENEM)

External institutions with authors

Deutsches Elektronen-Synchrotron DESY
European Synchrotron Radiation Facility (ESRF)
Helmholtz-Zentrum Geesthacht Zentrum für Material- und Küstenforschung GmbH (HZG)
Institute Laue-Langevin (ILL)
Technische Universität München (TUM)
Universitätsklinikum Jena

Research Fields

A2 Nanoanalysis and Microscopy
Exzellenz-Cluster Engineering of Advanced Materials

How to cite

Schmiele, M., Busch, S., Morhenn, H., Schindler, T., Schmutzler, T., Schweins, R.,... Unruh, T. (2016). Structural Characterization of Lecithin-Stabilized Tetracosane Lipid Nanoparticles. Part II: Suspensions. Journal of Physical Chemistry B, 120(24), 5513-5526.

Schmiele, Martin, et al. "Structural Characterization of Lecithin-Stabilized Tetracosane Lipid Nanoparticles. Part II: Suspensions." Journal of Physical Chemistry B 120.24 (2016): 5513-5526.


Last updated on 2019-04-06 at 15:23