Distinct functions of the laminin beta LN domain and collagen IV during cardiac extracellular matrix formation and stabilization of alary muscle attachments revealed by EMS mutagenesis in Drosophila

Beitrag in einer Fachzeitschrift
(Originalarbeit)


Details zur Publikation

Autorinnen und Autoren: Hollfelder D, Frasch M, Reim I
Zeitschrift: Bmc Developmental Biology
Verlag: BIOMED CENTRAL LTD
Jahr der Veröffentlichung: 2014
Band: 14
ISSN: 1471-213X


Abstract


Conclusions: Assembly of the cardiac ECM depends primarily on laminin, whereas collagen IV is needed for stabilization. Our data underscore the importance of a correctly assembled ECM particularly for the development of cardiac tissues and their lateral connections. The mutational analysis suggests that the beta 6/beta 3/beta 8 interface of the laminin beta LN domain is highly critical for formation of contiguous cardiac ECM layers. Certain mutations in the collagen IV triple helix-forming domain may exert a semi-dominant effect leading to an overall weakening of ECM structures as well as intracellular accumulation of collagen and other molecules, thus paralleling observations made in other organisms and in connection with collagen-related diseases.



FAU-Autorinnen und Autoren / FAU-Herausgeberinnen und Herausgeber

Frasch, Manfred Prof. Dr.
Lehrstuhl für Entwicklungsbiologie
Hollfelder, Dominik
Lehrstuhl für Entwicklungsbiologie
Reim, Ingolf PD Dr.
Lehrstuhl für Entwicklungsbiologie


Zitierweisen

APA:
Hollfelder, D., Frasch, M., & Reim, I. (2014). Distinct functions of the laminin beta LN domain and collagen IV during cardiac extracellular matrix formation and stabilization of alary muscle attachments revealed by EMS mutagenesis in Drosophila. Bmc Developmental Biology, 14. https://dx.doi.org/10.1186/1471-213X-14-26

MLA:
Hollfelder, Dominik, Manfred Frasch, and Ingolf Reim. "Distinct functions of the laminin beta LN domain and collagen IV during cardiac extracellular matrix formation and stabilization of alary muscle attachments revealed by EMS mutagenesis in Drosophila." Bmc Developmental Biology 14 (2014).

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