Asymmetric hydrogenation of methyl pyruvate in the continuous gas phase using Supported Ionic Liquid Phase (SILP) catalysis

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Details zur Publikation

Autor(en): Schneider M, Haumann M, Wasserscheid P
Zeitschrift: Journal of Molecular Catalysis A-Chemical
Verlag: Elsevier
Jahr der Veröffentlichung: 2013
Band: 376
Seitenbereich: 103-110
ISSN: 1381-1169


Abstract


Based on the recently reported asymmetric hydrogenation of methyl acetoacetate in a continuous-flow, gas phase reaction using Supported Ionic Liquid Phase (SILP) catalysis, this study deals with the even more challenging asymmetric reduction of the alpha-keto ester methyl pyruvate. Different support materials, ligands and ionic liquids were screened to identify an optimized Ru-based SILP catalyst. With Ru-BINAP dissolved in the ionic liquids 3-hydroxypropylpyridinium bis(trifluoromethylsulfonyl)imide on silica 100, stable catalyst performance could be obtained for more than 50 h time-on-stream. At 95 degrees C and with a residence time in the reactor of less than 3 s a stable product yield of 80-84% was obtained with moderate but stable enantiomeric excess of 26-30%. (C) 2013 Elsevier B.V. All rights reserved.



FAU-Autoren / FAU-Herausgeber

Haumann, Marco PD Dr.
Lehrstuhl für Chemische Reaktionstechnik
Schneider, Martin
Lehrstuhl für Chemische Reaktionstechnik
Wasserscheid, Peter Prof. Dr.
Lehrstuhl für Chemische Reaktionstechnik


Zitierweisen

APA:
Schneider, M., Haumann, M., & Wasserscheid, P. (2013). Asymmetric hydrogenation of methyl pyruvate in the continuous gas phase using Supported Ionic Liquid Phase (SILP) catalysis. Journal of Molecular Catalysis A-Chemical, 376, 103-110. https://dx.doi.org/10.1016/j.molcata.2013.04.022

MLA:
Schneider, Martin, Marco Haumann, and Peter Wasserscheid. "Asymmetric hydrogenation of methyl pyruvate in the continuous gas phase using Supported Ionic Liquid Phase (SILP) catalysis." Journal of Molecular Catalysis A-Chemical 376 (2013): 103-110.

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Zuletzt aktualisiert 2018-10-08 um 03:42