Schneider M, Haumann M, Wasserscheid P (2013)
Publication Status: Published
Publication Type: Journal article
Publication year: 2013
Publisher: Elsevier
Book Volume: 376
Pages Range: 103-110
DOI: 10.1016/j.molcata.2013.04.022
Based on the recently reported asymmetric hydrogenation of methyl acetoacetate in a continuous-flow, gas phase reaction using Supported Ionic Liquid Phase (SILP) catalysis, this study deals with the even more challenging asymmetric reduction of the alpha-keto ester methyl pyruvate. Different support materials, ligands and ionic liquids were screened to identify an optimized Ru-based SILP catalyst. With Ru-BINAP dissolved in the ionic liquids 3-hydroxypropylpyridinium bis(trifluoromethylsulfonyl)imide on silica 100, stable catalyst performance could be obtained for more than 50 h time-on-stream. At 95 degrees C and with a residence time in the reactor of less than 3 s a stable product yield of 80-84% was obtained with moderate but stable enantiomeric excess of 26-30%. (C) 2013 Elsevier B.V. All rights reserved.
APA:
Schneider, M., Haumann, M., & Wasserscheid, P. (2013). Asymmetric hydrogenation of methyl pyruvate in the continuous gas phase using Supported Ionic Liquid Phase (SILP) catalysis. Journal of Molecular Catalysis A-Chemical, 376, 103-110. https://dx.doi.org/10.1016/j.molcata.2013.04.022
MLA:
Schneider, Martin, Marco Haumann, and Peter Wasserscheid. "Asymmetric hydrogenation of methyl pyruvate in the continuous gas phase using Supported Ionic Liquid Phase (SILP) catalysis." Journal of Molecular Catalysis A-Chemical 376 (2013): 103-110.
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