Cobalt-Releasing 1393 Bioactive Glass-Derived Scaffolds for Bone Tissue Engineering Applications

Beitrag in einer Fachzeitschrift


Details zur Publikation

Autorinnen und Autoren: Hoppe A, Jokic B, Janackovic D, Fey T, Greil P, Romeis S, Schmidt J, Peukert W, Lao J, Jallot E, Boccaccini AR
Zeitschrift: ACS Applied Materials and Interfaces
Verlag: American Chemical Society
Jahr der Veröffentlichung: 2014
Band: 6
Seitenbereich: 2865-2877
ISSN: 1944-8244


Abstract


Loading biomaterials with angiogenic therapeutics has emerged as a promising approach for developing superior biomaterials for engineering bone constructs. In this context, cobalt-releasing materials are of interest as Co is a known angiogenic agent. In this study, we report on cobalt-releasing three-dimensional (3D) scaffolds based on a silicate bioactive glass. Novel melt-derived "1393" glass (53 wt % SiO2, 6 wt % Na2O, 12 wt % K2O, wt % MgO, 20 wt % CaO, and 4 wt % P2O5) with CoO substituted for CaO was fabricated and was used to produce a 3D porous scaffold by the foam replica technique. Glass structural and thermal properties as well as scaffold macrostructure, compressive strength, acellular bioactivity, and Co release in simulated body fluid (SBF) were investigated. In particular, detailed insights into the physicochemical reactions occurring at the scaffold-fluid interface were derived from advanced micro-particle-induced X-ray emission/Rutherford backscattering spectrometry analysis. CoO is shown to act in a concentration-dependent manner as both a network former and a network modifier. At a concentration of 5 wt % CoO, the glass transition point (T-g) of the glass was reduced because of the replacement of stronger Si-O bonds with Co-O bonds in the glass network. Compressive strengths of >2 MPa were measured for Co-containing 1393-derived scaffolds, which are comparable to values of human spongy bone. SBF studies showed that all glass scaffolds form a calcium phosphate (CaP) layer, and for 1393-1Co and 1393-5Co, CaP layers with incorporated traces of Co were observed. The highest Co concentrations of similar to 12 ppm were released in SBF after reaction for 21 days, which are known to be within therapeutic ranges reported for Co2+ ions.



FAU-Autorinnen und Autoren / FAU-Herausgeberinnen und Herausgeber

Boccaccini, Aldo R. Prof. Dr.-Ing.
Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)
Lehrstuhl für Feststoff- und Grenzflächenverfahrenstechnik
Fey, Tobias Dr.
Lehrstuhl für Werkstoffwissenschaften (Glas und Keramik)
Greil, Peter Prof. Dr.
Lehrstuhl für Werkstoffwissenschaften (Glas und Keramik)
Hoppe, Alexander
Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)
Peukert, Wolfgang Prof. Dr.-Ing.
Lehrstuhl für Feststoff- und Grenzflächenverfahrenstechnik
Romeis, Stefan Dr.-Ing.
Lehrstuhl für Feststoff- und Grenzflächenverfahrenstechnik
Schmidt, Jochen Dr.


Einrichtungen weiterer Autorinnen und Autoren

L’université Blaise Pascal (L'UBP) / Blaise Pascal University
University of Belgrade / Универзитет у Београду


Zitierweisen

APA:
Hoppe, A., Jokic, B., Janackovic, D., Fey, T., Greil, P., Romeis, S.,... Boccaccini, A.R. (2014). Cobalt-Releasing 1393 Bioactive Glass-Derived Scaffolds for Bone Tissue Engineering Applications. ACS Applied Materials and Interfaces, 6, 2865-2877. https://dx.doi.org/10.1021/am405354y

MLA:
Hoppe, Alexander, et al. "Cobalt-Releasing 1393 Bioactive Glass-Derived Scaffolds for Bone Tissue Engineering Applications." ACS Applied Materials and Interfaces 6 (2014): 2865-2877.

BibTeX: 

Zuletzt aktualisiert 2019-20-03 um 11:38