Solvent-Free Biginelli Reactions Catalyzed by Hierarchical Zeolite Utilizing a Ball Mill Technique: A Green Sustainable Process

Shahid A, Ahmed NSI, Saleh T, Al-Thabaiti SA, Basahel S, Schwieger W, Mokhtar M (2017)


Publication Status: Published

Publication Type: Journal article

Publication year: 2017

Journal

Publisher: MDPI AG

Book Volume: 7

Journal Issue: 3

DOI: 10.3390/catal7030084

Abstract

A sustainable, green one-pot process for the synthesis of dihydropyrimidinones (DHPMs) derivatives by a three-component reaction of beta-ketoester derivatives, aldehyde and urea or thiourea over the alkali-treated H-ZSM-5 zeolite under ball-milling was developed. Isolation of the product with ethyl acetate shadowed by vanishing of solvent was applied. The hierachical zeolite catalyst (MFI27_6) showed high yield (86%-96%) of DHPMs in a very short time (10-30 min). The recyclability of the catalyst for the subsequent reactions was examined in four subsequent runs. The catalyst was shown to be robust without a detectable reduction in catalytic activity, and high yields of products showed the efficient protocol of the Biginelli reactions.

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How to cite

APA:

Shahid, A., Ahmed, N.S.I., Saleh, T., Al-Thabaiti, S.A., Basahel, S., Schwieger, W., & Mokhtar, M. (2017). Solvent-Free Biginelli Reactions Catalyzed by Hierarchical Zeolite Utilizing a Ball Mill Technique: A Green Sustainable Process. Catalysts, 7(3). https://dx.doi.org/10.3390/catal7030084

MLA:

Shahid, Ameen, et al. "Solvent-Free Biginelli Reactions Catalyzed by Hierarchical Zeolite Utilizing a Ball Mill Technique: A Green Sustainable Process." Catalysts 7.3 (2017).

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