Conceptual design and feasibility study of combining continuous chromatography and crystallization for stereoisomer separations

Beitrag in einer Fachzeitschrift
(Originalarbeit)


Details zur Publikation

Autorinnen und Autoren: Gedicke K, Kaspereit M, Beckmann W, Budde U, Lorenz H, Seidel-Morgenstern A
Zeitschrift: Chemical Engineering Research & Design
Verlag: Elsevier
Jahr der Veröffentlichung: 2007
Band: 85
Seitenbereich: 928-936
ISSN: 0263-8762
Sprache: Englisch


Abstract


The separation of stereoisomers - diastereoisomers and enantiomers - constitutes an important class of problems in life science applications, namely in drug manufacture. Chromatography is often the method of choice to perform this task. To decrease the typically high investment and operational costs of the chromatographic separation, it can be beneficial to combine this process with a selective crystallization step. This work investigates such process combination of simulated moving bed chromatography and crystallization from solution. A short-cut method, based on only a few fundamental experimental parameters, is applied to evaluate the process combination for one enantiomeric and one epimeric system. While the enantiomeric system is characterized by a simple conglomerate phase diagram, the epimeric system shows some characteristic properties, like incorporation of the counter epimer and an additional impurity into the crystal lattice of the product epimer, that have to be accounted for by more detailed investigations. © 2007 Institution of Chemical Engineers.



FAU-Autorinnen und Autoren / FAU-Herausgeberinnen und Herausgeber

Kaspereit, Malte Prof. Dr.-Ing.
Professur für Thermische Verfahrenstechnik


Zitierweisen

APA:
Gedicke, K., Kaspereit, M., Beckmann, W., Budde, U., Lorenz, H., & Seidel-Morgenstern, A. (2007). Conceptual design and feasibility study of combining continuous chromatography and crystallization for stereoisomer separations. Chemical Engineering Research & Design, 85, 928-936. https://dx.doi.org/10.1205/cherd06224

MLA:
Gedicke, Knut, et al. "Conceptual design and feasibility study of combining continuous chromatography and crystallization for stereoisomer separations." Chemical Engineering Research & Design 85 (2007): 928-936.

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