Sarcopenic obesity: molecular clues to a better understanding of its pathogenesis?

Beitrag in einer Fachzeitschrift
(Review-Artikel)


Details zur Publikation

Autorinnen und Autoren: Kob R, Bollheimer C, Bertsch T, Fellner C, Djukic M, Sieber C, Fischer B
Zeitschrift: Biogerontology
Verlag: Springer Verlag (Germany)
Jahr der Veröffentlichung: 2015
Band: 16
Heftnummer: 1
Seitenbereich: 15-29
ISSN: 1389-5729


Abstract


An age-dependent decline in skeletal muscle mass, strength, and endurance during the aging process is a physiological development, but several factors may exacerbate this process, leading to the threatening state of sarcopenia, frailty, and eventually higher mortality rates. Obesity appears to be such a promoting factor and has been linked in several studies to sarcopenia. The reason for this causal association remains poorly understood. Notwithstanding the fact that a higher body mass might simply lead to diminished physical activity and therefore contribute to a decline in skeletal muscle, several molecular mechanisms have been hypothesized. There could be an obesity derived intracellular lipotoxicity (i.e., elevated intramuscular levels of lipids and their derivatives), which induces apoptosis by means of an elevated oxidative stress. Paracrine mechanisms and inflammatory cytokines, such as CRP and IL-6 could be confounders of the actual underlying pathological mechanism. Due to a cross-talk of the hypothalamo-pituitary axis with nutritional status, obese subjects are more in a catabolic state of metabolism, with a higher susceptibility to muscle wasting under energy restriction. Obesity induces insulin resistance in the skeletal muscle, which consequently leads to perturbed metabolism, and misrouted signaling in the muscle cells. In obesity, muscle progenitor cells could differentiate to an adipocyte-like phenotype as a result of paracrine signals from (adipo)cytokines leading to a reduced muscular renewal capacity. The present review outlines current knowledge concerning possible pathways, which might be involved in the molecular pathogenesis of sarcopenic obesity.



FAU-Autorinnen und Autoren / FAU-Herausgeberinnen und Herausgeber

Bollheimer, Cornelius Prof. Dr.
Professur für Innere Medizin - Geriatrie
Fischer, Barbara Dr.
Lehrstuhl für Innere Medizin (Geriatrie)
Kob, Robert Dr.
Professur für Innere Medizin - Geriatrie
Sieber, Cornel Prof. Dr.
Lehrstuhl für Innere Medizin (Geriatrie)


Einrichtungen weiterer Autorinnen und Autoren

Evangelisches Krankenhaus Göttingen-Weende
Paracelsus Medizinische Privatuniversität
Universitätsklinikum Regensburg


Zitierweisen

APA:
Kob, R., Bollheimer, C., Bertsch, T., Fellner, C., Djukic, M., Sieber, C., & Fischer, B. (2015). Sarcopenic obesity: molecular clues to a better understanding of its pathogenesis? Biogerontology, 16(1), 15-29. https://dx.doi.org/10.1007/s10522-014-9539-7

MLA:
Kob, Robert, et al. "Sarcopenic obesity: molecular clues to a better understanding of its pathogenesis?" Biogerontology 16.1 (2015): 15-29.

BibTeX: 

Zuletzt aktualisiert 2018-10-08 um 05:42