Effect of ferrocene-substituted porphyrin RL-91 on Candida albicans biofilm formation

Lippert R, Vojnovic S, Mitrovic A, Jux N, Ivanovic-Burmazovic I, Vasiljevic B, Stankovic N (2014)


Publication Status: Published

Publication Type: Journal article, Original article

Publication year: 2014

Journal

Book Volume: 24

Pages Range: 3506-3511

Journal Issue: 15

DOI: 10.1016/j.bmcl.2014.05.061

Abstract

Ferrocene-substituted porphyrin RL-91 exhibits antifungal activity against opportune human pathogen Candida albicans. RL-91 efficiently inhibits growth of both planktonic C. albicans cells and cells within biofilms without photoactivation. The minimal inhibitory concentration for plankton form (PMIC) was established to be 100 μg/mL and the same concentration killed 80% of sessile cells in the mature biofilm (SMIC80). Furthermore PMIC of RL-91 efficiently prevents C. albicans biofilm formation. RL-91 is cytotoxic for human fibroblasts in vitro in concentration of 10 μg/mL, however it does not cause hemolysis in concentrations of up to 50 μg/mL. These findings open possibility for application of RL-91 as an antifungal agent for external antibiofilm treatment of medical devices as well as a scaffold for further development of porphyrin based systemic antifungals. © 2014 Elsevier Ltd. All rights reserved.

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How to cite

APA:

Lippert, R., Vojnovic, S., Mitrovic, A., Jux, N., Ivanovic-Burmazovic, I., Vasiljevic, B., & Stankovic, N. (2014). Effect of ferrocene-substituted porphyrin RL-91 on Candida albicans biofilm formation. Bioorganic and Medicinal Chemistry Letters, 24(15), 3506-3511. https://dx.doi.org/10.1016/j.bmcl.2014.05.061

MLA:

Lippert, Rainer, et al. "Effect of ferrocene-substituted porphyrin RL-91 on Candida albicans biofilm formation." Bioorganic and Medicinal Chemistry Letters 24.15 (2014): 3506-3511.

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