Storkhead box 2 and melanoma inhibitory activity promote oral squamous cell carcinoma progression

Sasahira T, Nishiguchi Y, Fujiwara R, Kurihara M, Kirita T, Boßerhoff AK, Kuniyasu H (2016)

Publication Type: Journal article

Publication year: 2016

Journal

Oncotarget Impact Journals

Book Volume: 7

Pages Range: 26751-64

Journal Issue: 18

DOI: 10.18632/oncotarget.8495

Abstract

Storkhead box protein 2 (STOX2) is a transcriptional factor associated with pre-eclampsia with fetal growth restriction. We recently reported that melanoma inhibitory activity (MIA) promotes oral squamous cell carcinoma (OSCC) progression. However, the relationship between STOX2 and MIA remains unknown in malignancies.We used immunohistochemistry and PCR to investigate MIA and STOX2 expression in OSCC. We also performed functional analysis in human OSCC cells.MIA and STOX2 mRNA levels were higher in OSCCs than in normal oral epithelial cells, and upregulation of STOX2 was significantly correlated with overexpression of MIA. Immunostaining for STOX2 was associated with nodal metastasis (P = 0.0002) and MIA expression (P < 0.0001). Furthermore, MIA expression (P = 0.0035) and STOX2 expression (P = 0.0061) were associated with poor outcome in OSCCs. In vitro analysis using OSCC cells revealed that MIA increased expression of STOX2 by paracrine manner. Moreover, STOX2 accelerated OSCC cell growth, invasion, suppressed apoptosis, and enhanced resistance to paclitaxel, cisplatin, and 5-FU.Our results suggest that MIA-STOX2 signaling may be a useful diagnostic and therapeutic target in OSCCs.

Authors with CRIS profile

Anja Katrin Boßerhoff Lehrstuhl für Biochemie und Molekulare Medizin

Involved external institutions

Nara Medical University JP Japan (JP)

How to cite

APA:

Sasahira, T., Nishiguchi, Y., Fujiwara, R., Kurihara, M., Kirita, T., Boßerhoff, A.K., & Kuniyasu, H. (2016). Storkhead box 2 and melanoma inhibitory activity promote oral squamous cell carcinoma progression. Oncotarget, 7(18), 26751-64. https://dx.doi.org/10.18632/oncotarget.8495

MLA:

Sasahira, Tomonori, et al. "Storkhead box 2 and melanoma inhibitory activity promote oral squamous cell carcinoma progression." Oncotarget 7.18 (2016): 26751-64.

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