Deregulated Fcγ receptor expression in patients with CIDP.

Quast I, Cueni F, Nimmerjahn F, Tackenberg B, Luenemann JD (2015)

Publication Status: Published

Publication Type: Journal article

Publication year: 2015

Journal

Neurology, Neuroimmunology and Neuroinflammation Lippincott, Williams & Wilkins

Book Volume: 2

Pages Range: e148

Journal Issue: 5

DOI: 10.1212/NXI.0000000000000148

Abstract

OBJECTIVE\nTo evaluate the expression of activating and inhibitory Fc-gamma receptors (FcγRs) before and during clinically effective therapy with IV immunoglobulin (IVIg) in patients with chronic inflammatory demyelinating polyneuropathy (CIDP).\nMETHODS\nPeripheral blood leukocyte subsets, including classical CD14(high)CD16(-) and nonclassical inflammatory CD14(low)CD16(+) monocytes as well as naive CD19(+)CD27(-) and memory CD19(+)CD27(+) B cells, were obtained at baseline and monitored at 2 and 4-8 weeks after initiation of IVIg therapy.\nRESULTS\nCompared with healthy donors matched by age and sex, patients with CIDP showed increased expression levels of the activating high-affinity FcγR1 on CD14(high)CD16(-) (p < 0.001) and CD14(low)CD16(+) monocytes (p < 0.001). Expression of the activating low-affinity FcγRIIA was increased on CD14(low)CD16(+) monocytes (p = 0.023). Conversely, expression of the inhibitory FcγRIIB was reduced on naive (p = 0.009) and memory (p = 0.002) B cells as well as on CD14(high)CD16(-) monocytes (p = 0.046). Clinically effective IVIg therapy partially restored deregulated FcγR expression on B cell subsets and monocytes.\nCONCLUSIONS\nThe FcγR regulatory system is disturbed in patients with CIDP. Balancing activating vs inhibitory FcγR expression might provide a clinical benefit for patients with CIDP.

Authors with CRIS profile

Falk Nimmerjahn Lehrstuhl für Genetik

Involved external institutions

Philipps-Universität Marburg DE Germany (DE) University of Zurich / Universität Zürich (UZH) CH Switzerland (CH)

How to cite

APA:

Quast, I., Cueni, F., Nimmerjahn, F., Tackenberg, B., & Luenemann, J.D. (2015). Deregulated Fcγ receptor expression in patients with CIDP. Neurology, Neuroimmunology and Neuroinflammation, 2(5), e148. https://dx.doi.org/10.1212/NXI.0000000000000148

MLA:

Quast, Isaak, et al. "Deregulated Fcγ receptor expression in patients with CIDP." Neurology, Neuroimmunology and Neuroinflammation 2.5 (2015): e148.

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