An Org-1-Tup transcriptional cascade reveals different types of alary muscles connecting internal organs in Drosophila

Beitrag in einer Fachzeitschrift
(Originalarbeit)


Details zur Publikation

Autorinnen und Autoren: Boukhatmi H, Schaub C, Bataille L, Reim I, Frendo JL, Frasch M, Vincent A
Zeitschrift: Development
Verlag: COMPANY OF BIOLOGISTS LTD
Jahr der Veröffentlichung: 2014
Band: 141
Heftnummer: 19
Seitenbereich: 3761-3771
ISSN: 0950-1991
eISSN: 1477-9129


Abstract


The T-box transcription factor Tbx1 and the LIM-homeodomain transcription factor Islet1 are key components in regulatory circuits that generate myogenic and cardiogenic lineage diversity in chordates. We show here that Org-1 and Tup, the Drosophila orthologs of Tbx1 and Islet1, are co-expressed and required for formation of the heart-associated alary muscles (AMs) in the abdomen. The same holds true for lineage-related muscles in the thorax that have not been described previously, which we name thoracic alary-related muscles (TARMs). Lineage analyses identified the progenitor cell for each AM and TARM. Three-dimensional high-resolution analyses indicate that AMs and TARMs connect the exoskeleton to the aorta/heart and to different regions of the midgut, respectively, and surround-specific tracheal branches, pointing to an architectural role in the internal anatomy of the larva. Org-1 controls tup expression in the AM/TARM lineage by direct binding to two regulatory sites within an AM/TARM-specific cis-regulatory module, tupAME. The contributions of Org-1 and Tup to the specification of Drosophila AMs and TARMs provide new insights into the transcriptional control of Drosophila larval muscle diversification and highlight new parallels with gene regulatory networks involved in the specification of cardiopharyngeal mesodermal derivatives in chordates.



FAU-Autorinnen und Autoren / FAU-Herausgeberinnen und Herausgeber

Frasch, Manfred Prof. Dr.
Lehrstuhl für Entwicklungsbiologie
Reim, Ingolf PD Dr.
Lehrstuhl für Entwicklungsbiologie
Schaub, Christoph Dr.
Lehrstuhl für Entwicklungsbiologie


Einrichtungen weiterer Autorinnen und Autoren

Université Toulouse III - Paul Sabatier


Zitierweisen

APA:
Boukhatmi, H., Schaub, C., Bataille, L., Reim, I., Frendo, J.-L., Frasch, M., & Vincent, A. (2014). An Org-1-Tup transcriptional cascade reveals different types of alary muscles connecting internal organs in Drosophila. Development, 141(19), 3761-3771. https://dx.doi.org/10.1242/dev.111005

MLA:
Boukhatmi, Hadi, et al. "An Org-1-Tup transcriptional cascade reveals different types of alary muscles connecting internal organs in Drosophila." Development 141.19 (2014): 3761-3771.

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