An Org-1-Tup transcriptional cascade reveals different types of alary muscles connecting internal organs in Drosophila
Boukhatmi H, Schaub C, Bataille L, Reim I, Frendo JL, Frasch M, Vincent A (2014)
Publication Status: Published
Publication Type: Journal article, Original article
Publication year: 2014
Journal
Publisher: COMPANY OF BIOLOGISTS LTD
Book Volume: 141
Pages Range: 3761-3771
Journal Issue: 19
DOI: 10.1242/dev.111005
Abstract
The T-box transcription factor Tbx1 and the LIM-homeodomain transcription factor Islet1 are key components in regulatory circuits that generate myogenic and cardiogenic lineage diversity in chordates. We show here that Org-1 and Tup, the Drosophila orthologs of Tbx1 and Islet1, are co-expressed and required for formation of the heart-associated alary muscles (AMs) in the abdomen. The same holds true for lineage-related muscles in the thorax that have not been described previously, which we name thoracic alary-related muscles (TARMs). Lineage analyses identified the progenitor cell for each AM and TARM. Three-dimensional high-resolution analyses indicate that AMs and TARMs connect the exoskeleton to the aorta/heart and to different regions of the midgut, respectively, and surround-specific tracheal branches, pointing to an architectural role in the internal anatomy of the larva. Org-1 controls tup expression in the AM/TARM lineage by direct binding to two regulatory sites within an AM/TARM-specific cis-regulatory module, tupAME. The contributions of Org-1 and Tup to the specification of Drosophila AMs and TARMs provide new insights into the transcriptional control of Drosophila larval muscle diversification and highlight new parallels with gene regulatory networks involved in the specification of cardiopharyngeal mesodermal derivatives in chordates.
Authors with CRIS profile
Christoph Schaub
Lehrstuhl für Entwicklungsbiologie
Ingolf Reim
Lehrstuhl für Entwicklungsbiologie
Manfred Frasch
Lehrstuhl für Entwicklungsbiologie
Involved external institutions
France (FR)How to cite
APA:
Boukhatmi, H., Schaub, C., Bataille, L., Reim, I., Frendo, J.-L., Frasch, M., & Vincent, A. (2014). An Org-1-Tup transcriptional cascade reveals different types of alary muscles connecting internal organs in Drosophila. Development, 141(19), 3761-3771. https://dx.doi.org/10.1242/dev.111005
MLA:
Boukhatmi, Hadi, et al. "An Org-1-Tup transcriptional cascade reveals different types of alary muscles connecting internal organs in Drosophila." Development 141.19 (2014): 3761-3771.
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