MicroRNAs in muscle differentiation: lessons from Drosophila and beyond

Beitrag in einer Fachzeitschrift

Details zur Publikation

Autorinnen und Autoren: Frasch M, Nguyen H
Zeitschrift: Current Opinion in Genetics & Development
Jahr der Veröffentlichung: 2006
Band: 16
Heftnummer: 5
Seitenbereich: 533-539
ISSN: 0959-437X


The mesoderm- and muscle-specific expression of microRNAs observed in a wide range of organisms suggests that post-transcriptional regulation by microRNAs can contribute significantly to the regulation of muscle development and physiology. One of these microRNAs, miR-1, is among the most widely conserved microRNAs during evolution. Genetic inactivation of miR-1 in Drosophila has shown that miR-1 is essential for maintaining the development and integrity of body wall muscles during phases of rapid growth, whereas it is not needed for normal mesoderm patterning and muscle specification. Expression analysis of a large set of potential miR-1 target mRNAs has revealed that these mRNAs tend to be expressed in non-muscle tissues, in patterns that are mutually exclusive with miR-1. Together, these findings lend support to the hypothesis that miR-1 exerts 'quality control' during muscle development by blocking detrimental mRNAs that are promiscuously expressed. Other miRNAs might promote specific developmental switches during the development and regeneration of muscles.

FAU-Autorinnen und Autoren / FAU-Herausgeberinnen und Herausgeber

Frasch, Manfred Prof. Dr.
Lehrstuhl für Entwicklungsbiologie
Nguyen, Hanh Dr.
Lehrstuhl für Entwicklungsbiologie


Frasch, M., & Nguyen, H. (2006). MicroRNAs in muscle differentiation: lessons from Drosophila and beyond. Current Opinion in Genetics & Development, 16(5), 533-539. https://dx.doi.org/10.1016/j.gde.2006.08.010

Frasch, Manfred, and Hanh Nguyen. "MicroRNAs in muscle differentiation: lessons from Drosophila and beyond." Current Opinion in Genetics & Development 16.5 (2006): 533-539.


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