Chromatographic separation and identification of a water-soluble dendritic methano[60]fullerene octadecaacid

Gharbi N, Burghardt S, Brettreich M, Herrenknecht C, Tamisier-Karolak S, Bensasson RV, Szwarc H, Hirsch A, Wilson S, Moussa F (2003)

Publication Type: Journal article, Original article

Publication year: 2003

Journal

Analytical Chemistry American Chemical Society

Original Authors: Gharbi N., Burghardt S., Brettreich M., Herrenknecht C., Tamisier-Karolak S., Bensasson R.V., Szwarc H., Hirsch A., Wilson S.R., Moussa F.

Publisher: American Chemical Society

Book Volume: 75

Pages Range: 4217-4222

Journal Issue: 16

DOI: 10.1021/ac026419k

Abstract

The chromatographic separation of a highly water-soluble dendritic monoadduct methanol 60]fullerene octadecaacid (dendrofullerene) with octadecylsilica bonded phases has been studied. It has been found that the RP-HPLC behavior of this dendrofullerene obeys the general rules of stationary-phase and mobile-phase selection for controlling the separation of usually acidic compounds. An RP-HPLC-ESI-MS analysis confirms the identity of the dendrofullerene and allows characterization of the molecular weights of the main impurities contained in the sample. The described methods can control the synthesis and efficiently purify this fullerene derivative, which has been previously shown to be active against mutant infectious clones of HIV-1, which are resistant to AZT and 3TC, drugs that are widely used in AIDS therapy.

Authors with CRIS profile

Michael Brettreich Lehrstuhl für Organische Chemie II Andreas Hirsch Lehrstuhl für Organische Chemie II

Involved external institutions

National Center for Scientific Research / Centre national de la recherche scientifique (CNRS) FR France (FR)

How to cite

APA:

Gharbi, N., Burghardt, S., Brettreich, M., Herrenknecht, C., Tamisier-Karolak, S., Bensasson, R.V.,... Moussa, F. (2003). Chromatographic separation and identification of a water-soluble dendritic methano[60]fullerene octadecaacid. Analytical Chemistry, 75(16), 4217-4222. https://doi.org/10.1021/ac026419k

MLA:

Gharbi, Najla, et al. "Chromatographic separation and identification of a water-soluble dendritic methano[60]fullerene octadecaacid." Analytical Chemistry 75.16 (2003): 4217-4222.

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