Densely packed Gd(III)-chelates with fast water exchange on a calix[4]arene scaffold: A potential MRI contrast agent

Beitrag in einer Fachzeitschrift
(Originalarbeit)


Details zur Publikation

Autorinnen und Autoren: Schühle DT, Polasek M, Lukes I, Chauvin T, Toth E, Schatz J, Hanefeld U, Stuart MCA, Peters JA
Zeitschrift: Dalton Transactions
Verlag: Royal Society of Chemistry
Jahr der Veröffentlichung: 2010
Band: 39
Heftnummer: 1
Seitenbereich: 185-191
ISSN: 1477-9226
eISSN: 1477-9234


Abstract


A pyridine-N-oxide functionalized DOTA analogue has been conjugated to a calix[4]arene and the corresponding Gd-complex was characterized with respect to its suitability as MRI contrast agent. The compound forms spherical micelles in water with a cmc of 35 μM and a radius of 8.2 nm. The relaxivity of these aggregates is 31.2 s mM at 25 °C and 20 MHz, which corresponds to a molecular relaxivity of 125 s mM. The high relaxivity mainly originates from the short τ (72.7 ns) and the size of the micelles. The interaction with bovine serum albumin (BSA) was studied and an observed relaxivity of up to 40.8 s mM (163.2 s mM per binding place) at 20 MHz and 37 °C was found in the presence of 2.0 mM protein. © The Royal Society of Chemistry 2010.



FAU-Autorinnen und Autoren / FAU-Herausgeberinnen und Herausgeber

Schatz, Jürgen Prof. Dr.
Professur für Organische Chemie


Einrichtungen weiterer Autorinnen und Autoren

Delft University of Technology
National Center for Scientific Research / Centre national de la recherche scientifique (CNRS)
University of Groningen / Rijksuniversiteit Groningen
Univerzita Karlova v Praze / Charles University in Prague


Zitierweisen

APA:
Schühle, D.T., Polasek, M., Lukes, I., Chauvin, T., Toth, E., Schatz, J.,... Peters, J.A. (2010). Densely packed Gd(III)-chelates with fast water exchange on a calix[4]arene scaffold: A potential MRI contrast agent. Dalton Transactions, 39(1), 185-191. https://dx.doi.org/10.1039/b917673j

MLA:
Schühle, Daniel T., et al. "Densely packed Gd(III)-chelates with fast water exchange on a calix[4]arene scaffold: A potential MRI contrast agent." Dalton Transactions 39.1 (2010): 185-191.

BibTeX: 

Zuletzt aktualisiert 2019-06-08 um 09:18