Combination of olefin metathesis and enzymatic ester hydrolysis in aqueous media in a one-pot synthesis

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(Originalarbeit)


Details zur Publikation

Autor(en): Tenbrink K, Seßler M, Schatz J, Gröger H
Zeitschrift: Advanced Synthesis & Catalysis
Verlag: Wiley-VCH Verlag
Jahr der Veröffentlichung: 2011
Band: 353
Heftnummer: 13
Seitenbereich: 2363-2367
ISSN: 1615-4150


Abstract


A new synthetic method for the preparation of cyclic malonic acid monoesters in aqueous media was developed based on the combination of a metathesis reaction and subsequent biocatalytic hydrolysis with a pig liver esterase in a one-pot synthesis. Both reaction steps proceed smoothly under optimized conditions in aqueous media requiring only a low amount of the metal catalyst for the metathesis reaction. Notably, the applied biocatalyst turned out to be highly compatible with the metal catalyst showing no significant influence on the enzyme activity. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.



FAU-Autoren / FAU-Herausgeber

Schatz, Jürgen Prof. Dr.
Professur für Organische Chemie
Seßler, Miriam
Graduiertenzentrum der FAU


Zitierweisen

APA:
Tenbrink, K., Seßler, M., Schatz, J., & Gröger, H. (2011). Combination of olefin metathesis and enzymatic ester hydrolysis in aqueous media in a one-pot synthesis. Advanced Synthesis & Catalysis, 353(13), 2363-2367. https://dx.doi.org/10.1002/adsc.201100403

MLA:
Tenbrink, Katharina, et al. "Combination of olefin metathesis and enzymatic ester hydrolysis in aqueous media in a one-pot synthesis." Advanced Synthesis & Catalysis 353.13 (2011): 2363-2367.

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