Anti-tumor and anti-leishmanial evaluations of 1,3,4-oxadiazine, pyran derivatives derived from cross-coupling reactions of β-bromo-6H-1,3,4- oxadiazine derivatives

Beitrag in einer Fachzeitschrift
(Originalarbeit)


Details zur Publikation

Autor(en): Mohareb RM, Schatz J
Zeitschrift: Bioorganic & Medicinal Chemistry
Verlag: Elsevier
Jahr der Veröffentlichung: 2011
Band: 19
Heftnummer: 8
Seitenbereich: 2707-2713
ISSN: 0968-0896


Abstract


Cyanoacetylhydrazine reacted with the ω-bromoacetophenones 2a,b to give hydrazide-hydrazone derivatives 3a,b. The latter products were cyclized to the 1,3,4-oxadiazine derivatives 4a,b. Bromination of the latter products gave the 6-bromo-6H-1,3,4-oxadiazine derivatives 5a,b which underwent a series of cross-coupling reactions. The antitumor evaluation of the newly synthesized products against the three cancer cells namely breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460) and CNS cancer (SF-268) showed that some of them have high inhibitory effect towards three cell lines which is higher than the standard. Moreover, the anti-leishmanial activity of the newly synthesized product was tested on Leishmania donovani amastigotes showed that some compounds have high activity. © 2011 Published by Elsevier Ltd. All rights reserved.



FAU-Autoren / FAU-Herausgeber

Schatz, Jürgen Prof. Dr.
Professur für Organische Chemie


Zitierweisen

APA:
Mohareb, R.M., & Schatz, J. (2011). Anti-tumor and anti-leishmanial evaluations of 1,3,4-oxadiazine, pyran derivatives derived from cross-coupling reactions of β-bromo-6H-1,3,4- oxadiazine derivatives. Bioorganic & Medicinal Chemistry, 19(8), 2707-2713. https://dx.doi.org/10.1016/j.bmc.2011.02.051

MLA:
Mohareb, Rafat Milad, and Jürgen Schatz. "Anti-tumor and anti-leishmanial evaluations of 1,3,4-oxadiazine, pyran derivatives derived from cross-coupling reactions of β-bromo-6H-1,3,4- oxadiazine derivatives." Bioorganic & Medicinal Chemistry 19.8 (2011): 2707-2713.

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