Is manganese (II) pentaazamacrocyclic superoxide dismutase mimic beneficial for human sperm mitochondria function and motility?

Otasevic V, Korac A, Vucetic M, MacAnovic B, Garalejic E, Ivanovic-Burmazovic I, Filipovic M, Buzadzic B, Stancic A, Jankovic A, Velickovic K, Golic I, Markelic M, Korac B (2013)


Publication Type: Journal article, Review article

Publication year: 2013

Journal

Original Authors: Otasevic V., Korac A., Vucetic M., MacAnovic B., Garalejic E., Ivanovic-Burmazovic I., Filipovic M., Buzadzic B., Stancic A., Jankovic A., Velickovic K., Golic I., Markelic M., Korac B.

Publisher: Mary Ann Liebert

Book Volume: 18

Pages Range: 170-178

Journal Issue: 2

DOI: 10.1089/ars.2012.4684

Abstract

Mitochondria play an important role in sperm cell maturation and function. Here, we examined whether (and how) changes in sperm redox milieu affect the functional status of sperm mitochondria, that is, sperm functionality. Compared with the control, incubation in Tyrode's medium for 3 h, under noncapacitating conditions, decreased sperm motility, the amount of nitric oxide (.NO), the number of MitoTracker Green FM (MT-G) positive mitochondria, and the expression of complexes I and IV of the mitochondrial respiratory chain. In turn, superoxide dismutase (SOD) mimic (M40403) treatment restored/increased these parameters, as well as the expression of endothelial nitric oxide synthase, manganese SOD, and catalase. These data lead to the hypothesis that M40403 improves mitochondrial functional state and motility of spermatozoa, as well as.NO might be involved in the observed effects of the mimic. © 2013, Mary Ann Liebert, Inc.

Authors with CRIS profile

Involved external institutions

How to cite

APA:

Otasevic, V., Korac, A., Vucetic, M., MacAnovic, B., Garalejic, E., Ivanovic-Burmazovic, I.,... Korac, B. (2013). Is manganese (II) pentaazamacrocyclic superoxide dismutase mimic beneficial for human sperm mitochondria function and motility? Antioxidants & Redox Signaling, 18(2), 170-178. https://dx.doi.org/10.1089/ars.2012.4684

MLA:

Otasevic, Vesna, et al. "Is manganese (II) pentaazamacrocyclic superoxide dismutase mimic beneficial for human sperm mitochondria function and motility?" Antioxidants & Redox Signaling 18.2 (2013): 170-178.

BibTeX: Download