Total retinal blood flow measurement with ultrahigh speed swept source/Fourier domain OCT

Baumann B, Potsaid B, Kraus M, Liu JJ, Huang D, Hornegger J, Cable AE, Duker JS, Fujimoto JG (2011)

Publication Type: Journal article, Original article

Publication year: 2011

Journal

Biomedical Optics Express Optical Society of America

Original Authors: Baumann B., Potsaid B., Kraus M., Liu J., Huang D., Hornegger J., Cable A., Duker J., Fujimoto J.

Publisher: Optical Society of America

Book Volume: 2

Pages Range: 1539-1552

Journal Issue: 6

DOI: 10.1364/BOE.2.001539

Abstract

Doppler OCT provides depth-resolved information on flow in biological tissues. In this article, we demonstrate ultrahigh speed swept source/Fourier domain OCT for visualization and quantitative assessment of retinal blood flow. Using swept laser technology, the system operated in the 1050-nm wavelength range at a high axial scan rate of 200 kHz. The rapid imaging speed not only enables volumetric imaging with high axial scan densities, but also enables measurement of high flow velocities in the central retinal vessels. Deep penetration in the optic nerve and lamina cribrosa was achieved by imaging at 1-μm wavelengths. By analyzing en-face images extracted from 3D Doppler data sets, absolute flow in single vessels as well as total retinal blood flow was measured using a simple and robust protocol that does not require measurement of Doppler angles. The results from measurements in healthy eyes suggest that ultrahigh speed swept source/Fourier domain OCT could be a promising technique for volumetric imaging of retinal vasculature and quantitation of retinal blood flow in a wide range of retinal diseases. © 2011 Optical Society of America.

Authors with CRIS profile

Martin Kraus Lehrstuhl für Informatik 14 (Bild- und Sprachverarbeitung) Joachim Hornegger Lehrstuhl für Informatik 14 (Bild- und Sprachverarbeitung)

Involved external institutions

Massachusetts Institute of Technology (MIT) US United States (USA) (US) Oregon Health and Science University (OSHU) US United States (USA) (US) Advanced Imaging Group, Thorlabs Inc. US United States (USA) (US)

How to cite

APA:

Baumann, B., Potsaid, B., Kraus, M., Liu, J.J., Huang, D., Hornegger, J.,... Fujimoto, J.G. (2011). Total retinal blood flow measurement with ultrahigh speed swept source/Fourier domain OCT. Biomedical Optics Express, 2(6), 1539-1552. https://dx.doi.org/10.1364/BOE.2.001539

MLA:

Baumann, Bernhard, et al. "Total retinal blood flow measurement with ultrahigh speed swept source/Fourier domain OCT." Biomedical Optics Express 2.6 (2011): 1539-1552.

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