Initial Attatchment of rMSC and MG-63 Cells on Patterned Bioglass® Substrates

Detsch R, Guillon O, Wondraczek L, Boccaccini AR (2012)

Publication Type: Journal article

Publication year: 2012

Journal

Advanced Engineering Materials Wiley-VCH Verlag

Publisher: Wiley-VCH Verlag

Book Volume: 14

Pages Range: B38-B44

DOI: 10.1002/adem.201180068

Abstract

A soft lithography technique was used to introduce surface patterns on the surface of sintered bioactive glass substrates. Osteoblast-like MG-63 cells and rat mesenchymal stem cells (rMSC) seeded on micropatterned bioactive glass surfaces showed different behavior with rMSC exhibiting a better initial attachment than MG-63 cells. Both cytoskeleton formation and cell spreading of rMSC were supported by the bioactive surfaces. In addition, the structured surfaces seemed to guide MG-63 cells to a larger extent than rMSC. The in vitro results are important considering the continuous development of bone tissue scaffolds based on silicate bioactive glasses. Soft lithography technique based on micromolding can be applied to introduce well-defined micropatterns on the surface of sintered bioactive glass substrates. Investigations with osteoblast-like cells and mesenchymal stem cells indicate that surface microstructuring can affect cytocompatibility and enable the assessment of the effects that different topographies have on different cell types. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Authors with CRIS profile

Rainer Detsch Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Lothar Wondraczek Professur für Werkstoffwissenschaften (Glas und Keramik) Aldo Boccaccini Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)

Involved external institutions

Technische Universität Darmstadt DE Germany (DE)

How to cite

APA:

Detsch, R., Guillon, O., Wondraczek, L., & Boccaccini, A.R. (2012). Initial Attatchment of rMSC and MG-63 Cells on Patterned Bioglass® Substrates. Advanced Engineering Materials, 14, B38-B44. https://doi.org/10.1002/adem.201180068

MLA:

Detsch, Rainer, et al. "Initial Attatchment of rMSC and MG-63 Cells on Patterned Bioglass® Substrates." Advanced Engineering Materials 14 (2012): B38-B44.

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