Initial Attatchment of rMSC and MG-63 Cells on Patterned Bioglass® Substrates
Detsch R, Guillon O, Wondraczek L, Boccaccini AR (2012)
Publication Type: Journal article
Publication year: 2012
Journal
Publisher: Wiley-VCH Verlag
Book Volume: 14
Pages Range: B38-B44
Abstract
A soft lithography technique was used to introduce surface patterns on the surface of sintered bioactive glass substrates. Osteoblast-like MG-63 cells and rat mesenchymal stem cells (rMSC) seeded on micropatterned bioactive glass surfaces showed different behavior with rMSC exhibiting a better initial attachment than MG-63 cells. Both cytoskeleton formation and cell spreading of rMSC were supported by the bioactive surfaces. In addition, the structured surfaces seemed to guide MG-63 cells to a larger extent than rMSC. The in vitro results are important considering the continuous development of bone tissue scaffolds based on silicate bioactive glasses. Soft lithography technique based on micromolding can be applied to introduce well-defined micropatterns on the surface of sintered bioactive glass substrates. Investigations with osteoblast-like cells and mesenchymal stem cells indicate that surface microstructuring can affect cytocompatibility and enable the assessment of the effects that different topographies have on different cell types. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Authors with CRIS profile
Rainer Detsch
Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)
Lothar Wondraczek
Professur für Werkstoffwissenschaften (Glas und Keramik)
Aldo Boccaccini
Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)
Involved external institutions
Germany (DE)How to cite
APA:
Detsch, R., Guillon, O., Wondraczek, L., & Boccaccini, A.R. (2012). Initial Attatchment of rMSC and MG-63 Cells on Patterned Bioglass® Substrates. Advanced Engineering Materials, 14, B38-B44. https://dx.doi.org/10.1002/adem.201180068
MLA:
Detsch, Rainer, et al. "Initial Attatchment of rMSC and MG-63 Cells on Patterned Bioglass® Substrates." Advanced Engineering Materials 14 (2012): B38-B44.
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