Initial Attatchment of rMSC and MG-63 Cells on Patterned Bioglass® Substrates

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Details zur Publikation

Autorinnen und Autoren: Detsch R, Guillon O, Wondraczek L, Boccaccini AR
Zeitschrift: Advanced Engineering Materials
Verlag: Wiley-VCH Verlag
Jahr der Veröffentlichung: 2012
Band: 14
Seitenbereich: B38-B44
ISSN: 1438-1656


Abstract


A soft lithography technique was used to introduce surface patterns on the surface of sintered bioactive glass substrates. Osteoblast-like MG-63 cells and rat mesenchymal stem cells (rMSC) seeded on micropatterned bioactive glass surfaces showed different behavior with rMSC exhibiting a better initial attachment than MG-63 cells. Both cytoskeleton formation and cell spreading of rMSC were supported by the bioactive surfaces. In addition, the structured surfaces seemed to guide MG-63 cells to a larger extent than rMSC. The in vitro results are important considering the continuous development of bone tissue scaffolds based on silicate bioactive glasses. Soft lithography technique based on micromolding can be applied to introduce well-defined micropatterns on the surface of sintered bioactive glass substrates. Investigations with osteoblast-like cells and mesenchymal stem cells indicate that surface microstructuring can affect cytocompatibility and enable the assessment of the effects that different topographies have on different cell types. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.



FAU-Autorinnen und Autoren / FAU-Herausgeberinnen und Herausgeber

Boccaccini, Aldo R. Prof. Dr.-Ing.
Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)
Detsch, Rainer Dr.-Ing.
Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)
Wondraczek, Lothar Prof. Dr.-Ing.
Professur für Werkstoffwissenschaften (Glas und Keramik)


Einrichtungen weiterer Autorinnen und Autoren

Technische Universität Darmstadt


Zitierweisen

APA:
Detsch, R., Guillon, O., Wondraczek, L., & Boccaccini, A.R. (2012). Initial Attatchment of rMSC and MG-63 Cells on Patterned Bioglass® Substrates. Advanced Engineering Materials, 14, B38-B44. https://dx.doi.org/10.1002/adem.201180068

MLA:
Detsch, Rainer, et al. "Initial Attatchment of rMSC and MG-63 Cells on Patterned Bioglass® Substrates." Advanced Engineering Materials 14 (2012): B38-B44.

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