Lo PC, Frasch M (1997)
Publication Status: Published
Publication Type: Journal article, Original article
Publication year: 1997
Publisher: ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS
Book Volume: 190
Pages Range: 241-256
Journal Issue: 2
Adhesion of cells to one another and to extracellular matrices has major roles in morphogenetic processes during development. One important family of cell adhesion receptors are the integrins, which in Drosophila have crucial functions in at least two adhesion-mediated developmental events: embryonic muscle attachment and adhesion of the wing epithelia. We have cloned and characterized a gene (struthio) that is expressed in embryonic mesodermal and muscle cells, including cardioblasts, and epidermal muscle attachment sites in a pattern that is reminiscent of the expression pattern of the PS integrins. Maternal and zygotic transcripts are produced by this gene and encode similar proteins with two alternative carboxy tails. Both proteins contain identical KH domains, a protein sequence motif that is found in numerous proteins that interact with RNA. The struthio protein is highly homologous in a region including the KH domain to the mouse quaking and C. elegans gld-1 proteins, two developmentally important genes. Somatic homozygous clones of an embryonic lethal mutation in this gene (stru(1A122)) cause wing blisters and night impairment, phenotypes which are associated with PS integrin subunit mutations. Thus, the struthio gene encodes a putative RNA-binding protein that appears to regulate some aspects of Drosophila integrin functioning. (C) 1997 Academic Press.
APA:
Lo, P.C., & Frasch, M. (1997). A novel KH-domain protein mediates cell adhesion processes in Drosophila. Developmental Biology, 190(2), 241-256.
MLA:
Lo, Patrick CH, and Manfred Frasch. "A novel KH-domain protein mediates cell adhesion processes in Drosophila." Developmental Biology 190.2 (1997): 241-256.
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