Development and characterization of niobium-releasing silicate bioactive glasses for tissue engineering applications

Miguez-Pacheco V, de Ligny D, Schmidt J, Detsch R, Boccaccini AR (2018)


Publication Language: English

Publication Status: Published

Publication Type: Journal article

Publication year: 2018

Journal

Publisher: ELSEVIER SCI LTD

Book Volume: 38

Pages Range: 871-876

Journal Issue: 3

DOI: 10.1016/j.jeurceramsoc.2017.07.028

Abstract

Novel niobium-containing bioactive glass formulations (Nb-BGs) were designed, produced and used to fabricate sintered glass-ceramic granules to examine their in vitro bioactivity and angiogenic potential. Nb-BGs were prepared by melting and quenching. Afterwards, the glasses were crushed and milled into fine powders. These powders were used to make aqueous slurries which were poured into molds, dried and sintered to produce pellets, from which granules of 0.5-0.85 mm in size were obtained. In vitro bioactivity was tested by immersing the granules in simulated body fluid for up to 14 days. Cell biology tests were carried out by indirect culture of bone marrow stromal cells (ST-2) with supernatants resulting from incubation of BG granules in cell culture medium. The effect of dissolution products from Nb-BGs on the secretion of vascular endothelial growth factor (VEGF) was assessed to characterize the angiogenic potential of the new Nb-containing BG compositions.

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How to cite

APA:

Miguez-Pacheco, V., de Ligny, D., Schmidt, J., Detsch, R., & Boccaccini, A.R. (2018). Development and characterization of niobium-releasing silicate bioactive glasses for tissue engineering applications. Journal of the European Ceramic Society, 38(3), 871-876. https://doi.org/10.1016/j.jeurceramsoc.2017.07.028

MLA:

Miguez-Pacheco, Valentina, et al. "Development and characterization of niobium-releasing silicate bioactive glasses for tissue engineering applications." Journal of the European Ceramic Society 38.3 (2018): 871-876.

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