Development and characterization of niobium-releasing silicate bioactive glasses for tissue engineering applications

Beitrag in einer Fachzeitschrift


Details zur Publikation

Autor(en): Miguez-Pacheco V, de Ligny D, Schmidt J, Detsch R, Boccaccini AR
Zeitschrift: Journal of the European Ceramic Society
Verlag: ELSEVIER SCI LTD
Jahr der Veröffentlichung: 2018
Band: 38
Heftnummer: 3
Seitenbereich: 871-876
ISSN: 0955-2219
Sprache: Englisch


Abstract


Novel niobium-containing bioactive glass formulations (Nb-BGs) were designed, produced and used to fabricate sintered glass-ceramic granules to examine their in vitro bioactivity and angiogenic potential. Nb-BGs were prepared by melting and quenching. Afterwards, the glasses were crushed and milled into fine powders. These powders were used to make aqueous slurries which were poured into molds, dried and sintered to produce pellets, from which granules of 0.5-0.85 mm in size were obtained. In vitro bioactivity was tested by immersing the granules in simulated body fluid for up to 14 days. Cell biology tests were carried out by indirect culture of bone marrow stromal cells (ST-2) with supernatants resulting from incubation of BG granules in cell culture medium. The effect of dissolution products from Nb-BGs on the secretion of vascular endothelial growth factor (VEGF) was assessed to characterize the angiogenic potential of the new Nb-containing BG compositions.



FAU-Autoren / FAU-Herausgeber

Boccaccini, Aldo R. Prof. Dr.-Ing.
Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)
de Ligny, Dominique Prof. Dr.
Professur für Werkstoffwissenschaften (Glas und Keramik)
Detsch, Rainer Dr.-Ing.
Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)
Schmidt, Jochen Dr.
Lehrstuhl für Feststoff- und Grenzflächenverfahrenstechnik


Zitierweisen

APA:
Miguez-Pacheco, V., de Ligny, D., Schmidt, J., Detsch, R., & Boccaccini, A.R. (2018). Development and characterization of niobium-releasing silicate bioactive glasses for tissue engineering applications. Journal of the European Ceramic Society, 38(3), 871-876. https://dx.doi.org/10.1016/j.jeurceramsoc.2017.07.028

MLA:
Miguez-Pacheco, Valentina, et al. "Development and characterization of niobium-releasing silicate bioactive glasses for tissue engineering applications." Journal of the European Ceramic Society 38.3 (2018): 871-876.

BibTeX: 

Zuletzt aktualisiert 2019-02-01 um 20:10