Continuous production of single enantiomers at high yields by coupling single column chromatography, racemization, and nanofiltration

Beitrag in einer Fachzeitschrift
(Originalarbeit)


Details zur Publikation

Autorinnen und Autoren: Nimmig S, Kaspereit M
Zeitschrift: Chemical Engineering and Processing
Verlag: Elsevier
Jahr der Veröffentlichung: 2013
Band: 67
Seitenbereich: 89-98
ISSN: 0255-2701
Sprache: Englisch


Abstract


A process combining single-column chromatography, racemization and solvent removal by membrane filtration to produce single enantiomers at high yields is proposed and investigated. Shortcut design methods are developed for a basic design using only a single chromatogram as input without the need for dynamic process simulation. A detailed process model is used to elucidate the role of relevant parameters and process dynamics. Experimental investigation of the process in fully coupled operation demonstrate the capability of the concept to produce single enantiomers at high yield and purity, as well as the applicability of the proposed design methods. © 2012 Elsevier B.V.



FAU-Autorinnen und Autoren / FAU-Herausgeberinnen und Herausgeber

Kaspereit, Malte Prof. Dr.-Ing.
Professur für Thermische Verfahrenstechnik
Nimmig, Sebastian
Professur für Thermische Verfahrenstechnik


Zitierweisen

APA:
Nimmig, S., & Kaspereit, M. (2013). Continuous production of single enantiomers at high yields by coupling single column chromatography, racemization, and nanofiltration. Chemical Engineering and Processing, 67, 89-98. https://dx.doi.org/10.1016/j.cep.2012.10.013

MLA:
Nimmig, Sebastian, and Malte Kaspereit. "Continuous production of single enantiomers at high yields by coupling single column chromatography, racemization, and nanofiltration." Chemical Engineering and Processing 67 (2013): 89-98.

BibTeX: 

Zuletzt aktualisiert 2019-07-04 um 14:50